1.2.4- Triazole - from

Fig. 6.3 CycUc voltammogram (1st cycle) of sterling silver (92.5% Ag, 7.5% Cu) in 0.5M NaCH3COO, pH 4, v = lOmV/s copper and silver oxidation peaks, indicating surface passivation in presence of Ata (3-amino,1,2,4-triazole) (from [304])...

Ruccia and co-workers187, 188 also succeeded in obtaining some 1,2,4-triazoles from 3-amino-l,2,4-oxadiazoles by the series of reactions shown in Eq. (71). Isolation of the intermediate (99) could also be bypassed by heating 98 directly with the p-toluidine at 120°-170°. 

Fig. 9.6 Formation and degradation of 1,2,4-triazole from photocataiytic degradation of tnadimefon. A Triadinefon, O 1,2,4-Triazole.

The one-pot, three-component synthesis of 1,2,4-triazoles from primary amines, acyl hydrazines and dimethoxy-A(-A(-dimethylmethanamine [84] was utilized for the preparation of compounds 235 (Scheme 41), which were evaluated for their anticonvulsant and neurotoxic properties [85]. The anticonvulsant activity was measured in mice by the maximal electroshock test (MES) and the neurotoxicity in mice by the rotarod neurotoxicity test (Tox). The majority of the compounds... 

Insensitivity to photolysis is suggested by the formation of 1,2,4-triazoles from some other heterocycles. However, mesoionic 4-aryl-l-phenyl-l,2,4-triazolin-3-ones (44) are decomposed on photolysis as in Scheme 12 (72CC498) triazolinethiones lose sulfur only <70AJC631>. 

Other examples of the same type include the regioselective synthesis of 1-substituted 1,2,4-triazoles from either 4-aminotriazole (1) [Eq. (70)]... 

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