Bialamicol

About 3 grams of 0-methylcholine chloride are stirred at room temperature with an excess of phosgene dissolved in 50 grams of chloroform, for about 2 hours. Excess phosgene and hydrochloric acid are removed by distillation under vacuo. Additional chloroform is added to the syrup and the mixture is poured into excess ammonia dissolved in chloroform and cooled in solid carbon dioxide-acetone. The solid is filtered and extracted with hot absolutt alcohol. The solid in the alcohol is precipitated with ether, filtered, and recrystallized from isopropanol. The carbaminoyi- -methylcholine chloride obtained has a melting point of about 220°C. 

Chemical Name 3,3 -Bis[(diethylamino)methyl] -5,5 -di-(2-propenyl)-[1,1 -biphenyl] -4,4 -diol 

Paraformaldehyde (7.5 g) (0.25mol)and 18.3g (0.25 mol) of diethylamine are mixed in 25 cc of alcohol and warmed until a clear solution Is obtained. The solution is cooled and mixed with 26.6 g (0.10 mol) of 3.3 -diallyl-4,4 -biphenol in 25 cc of alcohol. After standing several hours, the solution is warmed for one hour on the steam bath, allowing the alcohol to boil off. The residue is then taken up in ether and water, the ether layer separated and washed with 2% sodium hydroxide solution and finally with water, The washed ether solution is dried over solid potassium carbonate, and filtered. After acidifying with alcoholic hydrogen chloride, the ether is distil led off and the alcoholic residue diluted with an equal volume of acetone. The crystalline hydrochloride is filtered off, triturated with alcohol, diluted with several volumes of acetone, filtered and dried MP 209°-210°C. 

Trade Name Manufacturer Country Year Introduced 

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Diethylacetylamino malonate Hydroxytryptophan Diet hy lal ly I-(1 -met hylbutyl) malonate Thiamylal Diethylamine Amodiaquin Benzquinamide Bialamicol Diethylpropion HCI Disulfiram Ethamivan... 

Bialamicol, chlorotrianisene, colchicine, dextromoramide (100°), diamthazole, hydrastine, mequitazine, naphthols, phenol, phenothiazine, thiocarlide... 

Dose. Bialamicol hydrochloride has been given in doses of 0.75 to 1.5 g daily. 

Quinidine Sulphate Amidephrine Mesylate Pipoxolan Hydrochloride Polythiazide Amodiaquine Guanoclor Sulphate Methyl Benzoquate Nalorphine Oxyclozanide Bamipine Hydrochloride Albendazole Chlormadinone Acetate Sulphamethizole Buprenorphine Fludrocortisone Acetate Hydroxyephedrine Hydrochloride Lormetazepam Sulphamethoxydiazine Bialamicol Hydrochloride Bunamidine Hydrochloride Hordenine Sulphate (dried) Mesterolone Carbidopa... 

BHT, 420 Bialamicol, 395 Bialamicol hydrochloride, 395 Biallylamicol, 395 Bibenzonium bromide, 396 Bicillin, 390, 926 Biciron, 1034... 

Drug 1 Drug 2 Twin drug Bialamicol Antiamoebic... 

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