Diethylamine Amodiaquin

Diethylacetylamino malonate Hydroxytryptophan Diet hy lal ly I-(1 -met hylbutyl) malonate Thiamylal Diethylamine Amodiaquin Benzquinamide Bialamicol Diethylpropion HCI Disulfiram Ethamivan... 

The inclusion of aromatic rings as part of the side chains results in quite potent agents, possibly because the rigid rings better define the position of the basic nitrogen. Reaction of para-hydroxyacetanilide (19-1) with formaldehyde and diethylamine affords the corresponding Mannich product (19-2) hydrolysis of the acetamide then leads to the aniline (19-3). Treatment of that compound with dichloro-quinoline (17-6) leads to the displacement of chlorine on the heterocyclic ring and the formation of amodiaquine (19-4) [21]. 

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