Betamethasone gel

Prepare the solution of items 1-3 at room temperature and solution of items 4 and 5 at about 6°C (or at 70°C). 

Mix both solutions. Maintain the temperature until the air bubbles disappeared. 

A certain amount of propylene glycol could be substituted by water. The obtained gel is clear and colorless. 

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Materials Required Silica gel G mobile-phase (1, 2-dichloroethane methanol water 95 5 0.2) 100 ml mixture of chloroform and methanol (9 1) 50 ml solution (1) betamethasone valerate sample 1. 5% w/v solution (2) betamethasone valerate BPCRS/EPCRS 1.5% w/v solution (3) a solution containing 0.030% w/v each of betamethasone EPCRS and betamethasone 21-valerate BPCRS alkaline tetrazolium blue solution q.s. ... 

Figure 3 Loss of betamethasone-17 valerate (in an isopropanol-containing polyacrylate gel) after a 20-minute irradiation. Source From Ref. 10.

In the treatment of secondarily infected dermatoses, which are usually colonized with streptococci, staphylococci, or both, compound antiinflammatory and antibacterial preparations are indicated when the underlying disorder has been diagnosed. Corticosteroids do not appear to inhibit the activity of antibacterial agents in compound preparations for topical application. Examples of topical compound preparations include betamethasone valerate-fusidic acid gel (for dogs), betamethasone sodium phosphate-neomycin sulphate cream (for dogs and cats), prednisolone-neomycin sulphate-nitrofurazone ointment (for horses, dogs and cats). The use of compound preparations is contra-indicated in pregnant animals. 

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