Betamethasone diproprionate

Diprosone lotion contains 0.05% betamethasone diproprionate. How many microliters of the lotion will contain 2.5 pg of the drug ... 

Intraarticular injections of insoluble corticosteroid depot suspensions directly into painful inflamed joints can give dramatic relief to arthritic patients that can last 3-4 weeks. This can be viewed as localized therapy. Microcrystalline suspensions of 6-methylpred-nisone acetate, betamethasone diproprionate, and dexamethasone 21-pivalate are among the effective agents. 

Superpotent formulations include clobetasol propionate, optimized betamethasone diproprionate, and difluorosone. These corticoids are grouped together since they are unique in being a class of compounds that are not only superpotent, but must be used with caution they have the potential for significant topical and systemic side effects far in excess of other currently utilized formulations. 

All absorbable corticoids possess the ability to produce adrenal suppression [11, 76]. The degree of suppression is related to potency. Comparative quantitative studies employ the Food and Drug Association s (FDA) diseased-skin protocol. As little as 14 g per week of clobetasol has induced suppression. Optimized betamethasone diproprionate is somewhat less suppressive, requiring over 49 g per week to significantly reduce plasma cortisol. Incomplete data with difluorosone suggests that it may be less suppressive. Fortunately, plasma cortisol usually returns to normal within 3 days when the superpotents are discontinued, at least in short-time application studies. 

Betamethasone diproprionate (Diproiene aeam) 0.05% tid for 1 wk starling at day 10 (to reduce redness)... 

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