Besylates

After having been washed with 50 cc of water the benzene layer is dried over potassium carbonate, filtered, allowed to stand over 10 g of alumina for about VA hours for partial decolorization, filtered again and concentrated under reduced pressure. The oily base which remains as a residue is directly converted into the tartrate. A solution cooled to 0°C, of 6.50 g of the free base in 100 cc of acetic acid ethyl ester is thoroughly shaken and poured into an ice cold solution of 2.66 g of tartaric acid in 410 cc of acetic acid ethyl ester. The precipitated, analytically pure, tartrate of 3-methylsulfinyl-10-[2 -N-methyl-piperidyl-2")-ethyl-1 ]-phenothiazine melts at 115° to 120°C (foam formation) and sinters above B0°C. The base Is reacted with benzene sulfonic acid in a suitable solvent to give the besylate. 

Mesoridazine besylate Methoqualone Metoclopramide HCI Metolazone Midazolam maleate Moxisylyte Nadolol Naloxone... 

CjHjBrO, 590-92-1) see Cisatracurium besylate 2-bromopropionitrile (CjH4BrN 19481-82-4) see Lofexidine 2-bromopropionyl bromide... 

C20H25NO4 73074-37-2) see Atracurium besilate (/t)-tetrabydropapaverine 7V-acetyl-L-leucinate (C2gH4(,N207 141109-12-8) see Cisatracurium besylate ( )-tetrabydropapaverine bydrocbloride (C20H26CINO4 6429-04-5) see Cisatracurium besylate [ -( , 5 )]-2,3,4,9-tetrabydro-7V-(l-phenylethyt)-lff-carbazol-3-amine sulfate (1 1)... 

Online detection using 4H nuclear magnetic resonance (NMR) is a detection mode that has become increasingly practical. In a recent application, cell culture supernatant was monitored on-line with 1-dimensional NMR for trehalose, P-D-pyranose, P-D-furanose, succinate, acetate and uridine.33 In stopped-flow mode, column fractions can also be analyzed by 2-D NMR. Reaction products of the preparation of the neuromuscular blocking compound atracurium besylate were separated on chiral HPLC and detected by 4H NMR.34 Ten isomeric peaks were separated on a cellulose-based phase and identified by online NMR in stopped-flow mode. 

Mistry, N., Roberts, A.D., Tranter, G.E., Francis, P., Barylski, I., Ismail, I.M., Nicholson, J.K., and Lindon, J.C., Directly coupled chiral HPLC-NMR and HPLC-CP spectroscopy as complementary methods for structural and enantiomeric isomer identification application to atracurium besylate, Anal. Chem., 71, 2838, 1999. 

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