Berkovitch-Yellin studies

This article would not be complete without reference to the recent studies of Addadi, Berkovitch-Yellin, Lahav, and Leiserowitz on the influence of impurities on crystal growth. However, this topic is the subject of a review elsewhere in this volume, and we therefore limit ourselves to a statement of the nature of the studies. 

Berkovitch-Yellin, Z. and Leiserowitz, L. (1980). The role of Coulomb forces in the crystal packing of amides a study based on experimental electron densities. J. Am. Chem. Soc. 102, 7677. 

Z. Berkovitch-Yellin and L. Leiserowitz, ]. Am. Chem. Soc., 102, 7677 (1980). The Role of Coulomb Forces in the Crystal Packing of Amides. A Study Based on Experimental Electron Densities. 

There has been a series of systematic studies of the effect of impurities and tailor-made additives on the shape of crystals grown from solution (Addadi et al. 1982 Berkovitch-Yellin 1985 Weissbuch et al. 1999.) They used amino acids and amino acid derivatives as model solutes. By combining habit observations with crystal structure and molecular orientation, they were able to rationalize a number of effects, including resolution of steroisomers. Hopefully, further studies in this area will provide a rational basis for the many impurity and additive effects found during crystallization of biochemicals. 

J. Wang, Z. Berkovitch-Yellin, and L. Leiserowitz, Location of tailor-made additives in the crystal and their effect on crystal habit. A study on the host-additive system L-asparagine-L-aspartic acid monohydrate, Acta Crystallogr., Sect. B, B41, 341-348 (1985). 

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