Digoxin Bepridil

Drugs that may be affected by fluoroquinolones include caffeine, cyclosporine, digoxin, antiarrhythmic agents, bepridil, erythromycin, phenothiazine, tricyclic antidepressants, procainamide, anticoagulants, and theophylline. 

Cardiovascular Acetyldigosin, ajmaline, amiodarone, aprindine, bepridil, bezaflbrate, captopril, dinepazide, clopidogrel, coumarins, diazoxide, digoxin, dipyridamole, disopyramide, doxazosin, enalapril, flurbiprofen, fur-oxemide, hydralazine, lisinopril methyldopa, metolazone, nifedipine, phenindione, procainamide, propanolol, propafenone, quinidine, ramapril, spironolactone, thiazide diuretics, ticlopidine, vesnarinone... 

Stern H, Aust P, Belz GG, Schneider HT. Interaction entre bepridil et digoxine. Rev Med 1983 24 1279. 

Interactions of digoxin with nitrendipine (182) and bepridil (183) have also been described. 

Belz GG, Wistuba S, Matthews JH. Digoxin and bepridil pharmacokinetic and pharmacodynamic interactions. Clin Pharmacol Ther 1986 39(1) 65-71. 

Clinically important, potentially hazardous interactions with abacavir, atorvastatin, bepridil, bupropion, carbamazepine, clarithromycin, cyclosporine, dexamethasone, digoxin, felodipine, fluticasone propionate, fosamprenavir, itraconazole, ketoconazole, lovastatin, methadone, midazolam, nicardipine, nifedipine, phenobarbital, phenytoin, rifabutin, simvastatin, sirolimus, St John s wort, systemic lidocaine, tacrolimus, tenofovir, trazodone, vinblastine, vincristine, voriconazole, warfarin, zidovudine... 

In 12 healthy subjects bepridil 300 mg daily for a week raised the serum levels of digoxin 375 micrograms daily by 34% (from 0.93 to 1.25 nanograms/mL). Five of them had mild to moderate headache, nausea and dizziness for 1 to 3 days shortly after concurrent use was started. The bradycardic effects of the two drugs were found to be additive, while the negative inotropic effects of the bepridil and the positive inotropism of the increased serum digoxin levels were almost balanced. ... 

In another study in 23 subjects given digoxin 250 micrograms and bepridil 300 mg daily for 14 days, peak plasma digoxin levels rose by 48% (from 1.49 to 2.2 nanograms/mL) and the AUC rose by 21%. ... 

Doose DR, Wallen S, NayakRK, MinnFL. Pharmacokinetic interaction of bepridil and digoxin at steady-state. Clin Pharmacol Ther 9% ) 41, 204. 

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