Benzyl derivatives 204 INDEX

Several benzyl derivatives exhibit potentially hazardous properties arising from the activation by the adjacent phenyl group, either of the substituent or of a hydrogen atom. Halides, in particular, are prone to autocatalytic Friedel Crafts polymerisation if the aromatic nucleus is not deactivated by electron withdrawing substituents. Individually indexed compounds are ... 

The dibenzylbutyrolactone lignan matairesinol was also found to be an anti-HIV agent [110], although the sample used in this bioassay was not isolated from a Taxus species. Another dibenzylbutyrolactone lignan, arctigenin, as well as its unsubstituted benzyl derivative exhibited anti-HIV replication activity, with EC50 values of 0.16 and 22 ig/mL and therapeutic index values of 5 and 9.1, respectively [111]. 

JIndianChemSoc 29, 46-8(1952) [Compd listed in 5th Decennial Formula Index 41-50 (1947-56), p 220F but not found in reference abstract CA 47, 2731(1953)] 2,4,6-TrlnHro-ctj-ehlorotoluene. See 2,4,6 -Trinitro-benzyl Chloride under Benzyl Chloride and Derivatives, Vol 2,p B95-R... 

At the end of the transformation, acetic anhydride in excess is hydrolyzed in acetic acid, which is directly titrated in the reaction medium with a sodium hydroxide solution in the presence of phenolphthalein. The same operations are realized with a blank in which there is no hydroxylated derivative, all the other experimental conditions being the same as in the assay. The difference between both volumes added gives the number of moles of acetic acid used for the esterification. The in pyridine acetylation index is of great interest in the analysis of essential vegetable oils, fats, and numerous pharmaceutical compounds, including, for instance, the determinations of cetylic and benzylic alcohols. The propionyl index is based on the same principle, but all of the operations are performed in a nonaqueous medium. 

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