Benzoyl hydrazide, reaction with

Benzotriazoles are neutral acylating agents, successfully used for the preparation of amides, oxamides and hydrazides The acylbenzotriazoles 95a-d are prepared from carboxylic acids 94a-d by reaction with l-methanesulfonyl-l//-benzotriazole (Scheme 51). Reaction of 1-benzoyl-l//-benzotriazole with hydroxylamine hydrochloride in the... 

Reaction with benzoic acid yields benzoyl hydrazide ... 

Several polydentate SBs may act as binucleating ligands see Section 33.5.12.1. Only a few miscellaneous polydentate SBs will be included here. A complex with the SB obtained in the reaction of two moles of benzoyl hydrazide with acetylacetone had v(V=0) = 995 cm 1, Pea =1.7BM and was monomeric square pyramidal (117).792 A few complexes with the ethylenediamine derivatives of 2,2 -dihydroxychalcones (118) were prepared in ethanol.793 The stoichiometry is 1 1 and the atoms involved in the coordination were two deprotonated oxygens and two nitrogen atoms. v(V—O) (970-985 cm-1) and f4 (1.73-1.83 BM) suggest a monomer however, molecular weights in nitrobenzene suggest a dimer. 

Various 2-substituted l,3,4-thiadiazoline-5-thiones can be prepared in good yield by the reaction of amidrazones with CS2 in ethanol at room temperature (Scheme 21a) (70CPB1696). 4-Aryl-2-benzoyl-5-imino-A2-l,3,4-thiadiazolines are prepared from activated thiocyanates and benzenediazonium chloride, presumably via a hydrazone (Scheme 21b) (75TL163). 2-Thio- and 2-amino-l,3,4-thiadiazoles carrying a carbamate in the 5-position are obtained in one step by the reaction of a dithioimidate with a hydrazide. The yields are quite high (Scheme 22a) (80ZC413). 

The synthesis of maleic acid hydrazide riboside (42) has been accomplished45 by the Hilbert-Johnson reaction of 38 with 2,3,5-tri-O-benzoyl-D-ribofuranosyl chloride in toluene at 100° in the presence... 

The products of the reaction between carboxylic acid hydrazides and carbon disulfide cyclize very readily to Zl4-l,3,4-oxadiazoline-2-thiones (LXXXIII) (see Section II.7). The intermediates, the acyl- or benzoyl-dithiocarbazic acids may, however, also be isolated and reacted with alkyl halides to give S-alkyl dithiocarbazates (LXXXVIIIa) which also cyclize easily either to thiadiazoline or oxadiazoline rings according to the reaction circumstances (see Section II.7). 

The chlorides derived from the reaction of aroyl phenylhydrazines with phosphorus pentachloride are recorded in the literature under a variety of names. While Chemical Abstracts lists these compounds as the phenyl-hydrazones of the corresponding acid chlorides (for example, benzoyl chloride phenylhydrazone for C H5CiCl)=NNHC H5), Beilstein uses the terms a-chlorobenzyliden phenylhydrazine or a-chlorobenzal phenyl-hydrazine for this compound. In view of the relationship of the chlorides I with the corresponding acid hydrazides (II), their hydrolysis products, the names hydrazide chlorides or hydrazidoyl chlorides are more appropriate. In order to preserve conformity of nomenclature, the latter name is used in this book. 

An example in this category is as follows (8,9) 4.2% carbobenzoxy-glycine and 3.7% aniline incubated with papain at 40° and at pH 4.6 gave an 80% yield of carbobenzoxyglycine anilide. The optimum pH and the necessity for activation by cysteine, glutathione, or HCl were the same as for the hydrolytic action of the enzyme. Acetyl, benzoyl, and carbobenzoxy derivatives of alanine, leucine, and phenylalanine yielded with aniline or phenylhydrazine the corresponding anilides or phenyl-hydrazides. Similar reactions were catalyzed by bromelin and cathepsin, proteolytic enzymes obtained respectively from pineapple and pig liver. Under the conditions which promoted the above syntheses, hippurylamide was completely hydrolyzed there was no synthrais of the amide from hippuric acid and ammonia. 

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