Benzotriazoles Benzotriazolides

Amino acids activated at the amino group by a benzotriazolide moiety react with amino acids under elimination of benzotriazole and C02 to give peptides. Reaction is achieved by warming up equimolar amounts of the components in anhydrous acetonitrile or aqueous acetone.[45] The benzotriazolylcarbonylamino acids are prepared from benzo-triazolyl-1-carboxylic acid chloride and amino acids.[46]... 

Carbonyl oxygen atoms of aldehydes can also be efficiently acylated by 1-acylbenzotriazoles 915 in the presence of mild bases (K2CO3, Et3N). The released benzotriazolide anions are consecutively attached to the aldehyde carbonyl carbon atoms to produce esters 944 (Equation 20). Aliphatic aldehydes react quickly at room temperature, but aromatic aldehydes require elevated temperatures. The yields are good to quantitative. The amounts of benzotriazol-2-yl isomers of esters 944 in the products mixtures is strongly dependent on the reaction conditions and the character of groups R1 and Rz, and it may vary from 5% to 25% <1999JHC777>. 

The products from benzotriazole, aldehydes and primary or secondary amines exist in the melt or in solution as equilibrium mixtures of 1- and 2-benzotriazolyl compounds, 99 and 100, whereas the solids are 1-benzotriazoles 99115. The equilibrium involves the resonance-stabilized aminomethyl cation and the delocalized benzotriazolide anion it accounts for the ease with which the bond attached to the benzotriazole moiety is cleaved. 

Methyl-1 H-benzotriazole, sodium salt Sodium 4(or 5)-methyl-1H-benzotriazolide Tolyltriazole, sodium salt. 

Sodium benzotriazolate Sodium 1 H-benzotriazolide Empirical CeHsNj Na Properties M.w. 141.11 Uses Corrosion inhibitor Manuf/Distrib. Yick-Vic Chems. Pharm. 

Synonyms Benzotriazole, sodium salt 1H-Benzotriazole, sodium salt Sodium benzotriazolate Sodium 1H-benzotriazolide... 

The benzotriazolide of the succinic half-ester of starch was prepared by reaction with 1-H-benzotriazole in the presence of ci-cyclohexylcarbodiimide. The reaction yield was about 66%, i.e., only about two out of three carboxyl groups were transformed into benzotriazolide groups ... 

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