Benzothiazole 2-methyl-6-nitro

Benzothiazole, 2-methyl-2-phenyl-2,3-dihydro-synthesis, 6, 325 Benzothiazole, 2-nitro-reactions, 6, 285 Benzothiazole, 5-nitro-nucleophilic attack, 5, 62 reactions... 

Benzothiazole, 3-methyl-N-ethyl-N-(3-cyanoethyl)aniline-4,2 -azo-6 -nitro-visible, 1, 343 <67MI11201)... 

Flash photolysis of misonidazole, metronidazole, and nitrobenzothiazoles has been carried out in [1369-1371], Laser flash-photolysis (355 nm) allows to determine relatively stable anion-radicals of misonidazole and metronidazole in aqueous solutions [1370], Solvated electrons have been formed at harder irradiation, the result of which interaction with nitroimidazole molecules is generation of their radical anions [1372], The authors [1372] have also found that fluorescence intensity of metronidazole is about 20 times more than that of misonidazole in same conditions. Photochromic properties of benzothiazole derivatives containing nitro and methyl groups in the ortho positions with respect to each other were studied by flash photolysis [1371], The application of the thermodynamic approach to predict the kinetic stability of formed nitronic acids is limited owing to specific intramolecular interactions. The lifetime of photoinduced nitronic acid anions tends to increase with rise in the chemical shift of the methyl protons. The rate constants photoinduced nitronic acids and their anions increase as the CH3C-CN02 bond becomes longer [1371],... 

Wahrend 4-(2-Nitro-phenylthiocarbonyl)-3-oxo-tetrahydropyran (konz. Ammoniak/Ethanol) analog zu 2-(2-Carboxymethoxy-ethyl)-l,3-benzothiazol-3-oxid reagiert (68% Schmp. 126-128°), erhalt man aus (l-Methyl-3-(2-nitro-phenylthio)-4-oxo-piperidin (Natronlauge/Te-trahydrofuran) unter zusatzlichcr Spaltung dcr C ,N-Bindung des Piperidin-Ringes 2-Formyl-1,3-benzothiazol (47% Schmp. 72-74°)81. 

Ethoxy carbonyl-5-methyl-7-nitro-l,3-benzothiazol (Chloroform A)... 

Methyl-propylaminocarbonyl)-7-nitro-5-trifluormethyl-l,3-benzothiazol-3-oxid ergibt bei der Be-... 

Bis-[l,3-Benzothiazol-2-ylthio]-organo- 997 Bis-[4-tert.-butyl-1,3-thiazol-2-yl]- 71 Bis-[l,3-dimethyl-lH-pyrazol-5-yl]- 557 Bis-[4,5-diphenyl-l,3-thiazol-2-yl]- 71 Bis-[4-methyl-l,3-thiazol-2-yl]- 71 Bis-[5-nitro-l,3-thiazol-2-yl]- 244 Bis-[l,3-thiazol-2-yl]- 70, 71 Ethyl- 337... 

Thiadiazoles are weak bases. On quatemization, e.g. with dimethyl sulfate, mixtures of 2- and 3-methyl-1,2,3-thiadiazoles are formed. Electrophilic substitution of the C-atoms could not be achieved. With 1,2,3-benzothiazoles, substitution occurs on the benzene ring. For instance, with nitric acid the 4- and 7-nitro-l,2,3-benzothiadiazoles are obtained. Nucleophiles bring about ring-opening, e.g. ... 

Jacobson-Hugershoff Synthesis (Type B CgHs—N—C—S).—Examples of compounds prepared by this well-established method include (oxidizing agent in parentheses) the imine (4) (Bra in CHCla), the 2-substituted benzothiazoles [1 R = CH(CN)C(0)Ph] (potassium ferricyanide), and the benzothiazoles (1 R = NHa, NHPh, etc.) variously substituted in the benzene ring with methyl, bromo-, chloro-, or nitro-groups (plumbophosphates). ... 

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