Benzoic butyric anhydride

Carboxylic acid fluorides are not of particular preparative importance since the reactions that can be carried out with them proceed analogously with the cheaper carboxylic acid chlorides. These fluorides are very stable, even towards hydrolysis. Formyl fluoride can be kept at room temperature for several hours before it decomposes into CO and HF. The preparation of carboxylic acid fluorides from the corresponding chlorides and KF was mentioned on page 204. If butyric anhydride is heated gradually to 180° with KHF2, butyryl fluoride, b.p. 67° 1167 mm, distils off, and benzoyl fluoride, b.p. 155-156°, can be obtained analogously from benzoic anhydride at 190-240°. KF can also be used in place of KHF2. Yields are around 80-90%.1079... 

The reaction of oarboxylate with various substrates is an example of a system which necessitates a careful search for products. Early examples of these reactions demonstrated that direct nucleophilic attack takes place. For example, using a dilatometric method, formate was found to catalyze strongly the hydrolysis of acetic anhydride whereas propionate and butyrate slow down the reaction (Kilpatrick, 1928). These results are attributable to mixed anhydride formation with the total rate being determined by the reactivity of the mixed anhydride. The reaction of acetate with 2,4-dinitrophenyl benzoate results in the formation of an unstable mixed anhydride, as was shown in an experiment in which 0 labeled acetate was used the benzoic acid product contains 75% of the O label (Bender and Neveu, 1958). The other 25 % of the O label is presumed to be lost to acetate by solvent attack at the benzoyl carbon if direct nucleophilic interaction is the sole path. 

Acetylated hydrogenated tallow glyceride Acetylated hydrogenated tallow glycerides Adipic acid Alkenyl succinic anhydride Ammonium citrate dibasic Behenic acid Behenyl alcohol Benzoic acid Benzothiazyl disulfide Benzyl butyrate Benzyltriethyl ammonium chloride 1-Butoxyethoxy-2-propanol Butoxytriglycol Butyl benzoate Butylcarbitol formal Butyl diglycol carbonate Butylene glycol n-Butyraldehyde C6-10 alcohols C8-10 alcohols... 

Organic adds. Acetic, formic, proplonlo, and butyric acids react rapidly with uranium In the presence of hydrogen chloride Benzoic acid In ether reacts with the metal, forming the benzoate Acetyl chloride 2Uid acetic anhydride react to form... 

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