Benzo central nervous system

Indoloazocines are useful as central nervous system depressants409 and also have shown some melatonin activity 410 Benzo[,(/]thieno[3,2-c]azocines have been employed as antidepressants.411... 

In addition to Minaprine, which has been marketed as an antidepressant, a number of other (benzo)pyridazine derivatives have been under investigation for their central nervous system activity. These include Endixaprine (187), a sedative hypnotic with a benzodiazepine-like profile, F-2692... 

Aminoethyl)benzo[ ]thiophene 4 has an even stronger action on the central nervous system than tryptamin. 

Most frequently used in these antagonism tests are reserpine and the benzo-quinolizine derivatives, tetrabenazine and Ro-4-1284. The latter 2 drugs have a more rapid onset of action and a more selective activity on the central nervous systems (CNS) than reserpine. Antagonism by test compounds of the induced hypothermia, ptosis (eyelid closure), miosis (decreased pupil diameter), and sedation is measured either separately or combined. Evidence has been presented [8] that hypothermia antagonism is a better indicator of CNS activity, as ptosis and miosis can be influenced also by drugs with a peripheral action [9]. 

Benzo[b]-3-thienylacetic acid (18) promotes plant growth, as does the corresponding indole compound. 3-(2-Arninoethyl)benzo[b]thiophene (19) has an even stronger action on the central nervous system than tryptamine. 

The determination of fhe embryonic "critical period of development" for the brain structures involved in learning and memory processes in mice is based on the original work by Rodier (1976). This study identified fhe embryonic time frames for peak neurogenesis and neuroepithelial proliferation for cerebral corfex, hippocampus, septum, amygdala, corpus striatum, thalamus, hypothalamus, cerebellum, and olfactory bulb as the period from embryonic day E14 fhrough E17. Rodier documented almost 40 years ago that the specific time of the central nervous system (CNS) insult is an important factor in subsequent effects on both anatomy and behavior. Therefore, this early work established what we refer to as the embryonic "critical period of development." The report suggested that the behavioral effects of toxicants such as benzo(a)pyrene (B(a)P) are similar in both rats and mice. This study was one of the first to demonstrate that mice could be used successfully as subjects in a variety of behavioral evaluation experiments. 

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