Benzene 1.2.4- trifluoro

F3CH, Methane, trifluoro-cadmium complex, 24 55, 59 mercury complex, 24 52 F3C6H2, Benzene, 1,3,5-trifluoro-thallium complex, 21 73 F3CIOC, Hypochlorous acid, trifluoro-methyl ester, 24 60... 

Fo 6oK2N4PtC4Ho w 3H20, Platinate, tetiacyano-, potassium (hydrogen difiuoride)-(1 2 0.30), 21 147 FjGiHj, Benzene, 1,3,5-trifluoro, thallium complex, 21 73... 

TABLE in-32. PHENYLATION OF THIAZOLE AND ALKYL-THIAZOLES IN TRIFLUORO ACETIC ACID SOLUTION WITH BEN20YLPEROXIDE (COM-PEirnON WITH BENZENE) AT 80°C (196). 

C6H6 BENZENE 81.512 1.5282E-01 2.6522E-05 129.66 289 C7H5F3 A,A,A-TRIFLUORO- -602.334 3.0018E-01 1.5014E-05 -511.28... 

At 320 °C, cesium tetrafluorocobaltate converts benzotrifluoride to /n-fluo-robenzotrifluoride, 2f/-heptafluorotoluene, octafluorotoluene, pertluoro-l -meth-ylcyclohexene, and perfluoromethylcyclohexane [29] l,3-Bis(trifluoromethyl)-benzene is convened at 420 °C to 4,5,6-trifluoro-l,3-bis(trifluoroethyl)bcnzene, perfluoro-l,3-dimethylbenzene, and perfluoro-l,3-dimethylcyclohexane [29], p-Xylene gives at 350 °C l,4-bis(difluoromethyl)tetrafluorobenzene, 1-di-fluoromethyl-3-trifluoromethyltetrafluorobenzene, perfluoro-1,3-dimethyl-benzene, and perfluoro-1,3-dimethyloyclohexane... 

Finally, rates of mercuration have been measured using mercuric trifluoro-acetate in trifluoroacetic acid at 25 °C450. The kinetics were pure second-order, with no reaction of the salt with the solvent and no isomerisation of the reaction products rate coefficients (10 k2) are as follows benzene, 2.85 toluene, 28.2 ethylbenzene, 24.4 i-propylbenzene, 21.1 t-butylbenzene, 17.2 fluorobenzene, 0.818 chlorobenzene, 0.134 bromobenzene, 0.113. The results follow the pattern noted above in that the reaction rates are much higher (e.g. for benzene, 690,000 times faster than for mercuration with mercuric acetate in acetic acid) yet the p factor is larger (-5.7) if the pattern is followed fully, one could expect a larger... 

Nesmeyanov et al.564 have measured the rates of deuteration of benzene and cyclopentadienylmanganese tricarbonyl by deuterated sulphuric acid-trifluoro-... 

Part C of the present procedure illustrates a mild method for effecting the elimination of thiophenol from thioacetals and thioketals under essentially neutral conditions. The reaction of simple thioacetals and thioketals with bis[copper(I) trifluoro-methanesulfonate] benzene complex in benzene-tetrahydrofuran at room temperature affords vinyl sulfides in high yield (Table I). The reaction presumably occurs by coordination of the thiophilic copper(I) reagent with sulfur, heterolysis to a phenylthio-stabilized... 

By use of TV-(trifluoroacetyl)- or TV-(trichloroacetyl)-imidazoleare obtained symmetric aliphatic and aromatic anhydrides even from carboxylic acids that do not form insoluble salts in benzene, ether, or THF (Table 13—1). In this case the acid is treated with the imidazolide in a 2 1 molar ratio, and an insoluble imidazolium trifluoro- or tri-chloroacetate is formed. 

Reaction of 2-cyanomethylpyridine with iV-(l-aryl-l-chloro-2,2,2-trifluoroethyl)-iV -(4-methylphenyl)carbodiimides, and with (1,1,2,2,2-pentachloro- and l,l-dichloro-2,2,2-trifluoroethyl)isocyanates or A-methoxycarbonyl-l,2,2,2-tetrachloro-, — l-chloro-2,2-trifluoroacetaldehyde imines afforded 3-aryl-4-cyano-l-(4-methylphenyl)imino-3-trifluoromethyl-2,3-dihydro-17/-pyrido[l,2-f]pyrimidines and 4-cyano-3-trichloro-, 4-cyano-3-trifluoro-17/-pyrido[l,2-4pyrimidin-l-ones, respectively <2004CHE47>. Refluxing 2-cyanomethylpyridine and iV-(l-aryl-l-chloro-2,2,2-trifluoroethyl)isocyanates in benzene furnished l-aryl-4-cyano-l-trifluoromethyl-l,2-dihydro-3//-pyrido[l,2-4pyrimidin-3-ones. However, when the solution of the isocyanate was added dropwise to the solution of 2-cyanomethylpyridine, and the reaction mixture was then treated with NEt at room temperature, the isomeric 3-aryl-4-cyano-3-trifluoromethyl-2,3-dihydro-l//-pyr-ido[l,2-dpyrimidin-l-ones were obtained. Reaction of l-(acetyl- and benzoylmethylene)-6,7-dimethoxy-l,2,3,4-tetra-hydroisoquinolines with PhCONCS yielded 1-acetyl-, 1 -benzoyl-9,10-dime thoxy-3-pheny 1-6,7-dihydro-2//-pyrimido[6,l- ]isoquinoline-2-thiones <2003SL2369>. 

Bromoanlsole Anisole, o-bromo- (8) Benzene, 1-bromo-2-methoxy- (9) (578-57-4) Methyl trifluoromethanesulfonate Methanesulfonic add, trifluoro-, methyl ester (8,9) (333-27-7)... 

Z)-1,1,1-TRIFLUORO-2-ETHOXY-5-PHENYL-2-PENTENE BENZENE, (4-ETHOXY-5,5,5-TRIFLUORO-3-PENTENYL)-, (Z)- (141708-71-6), 75, 153... 

Substituent effects on benzene photochemistry in the presence of amines are described53 in equations 19-21. The a-C—H of an amine is shown to add photolytically to the 2,5-positions of toluene (equation 19). In contrast, trifluoro-substituted benzene was excited to react with trimethylamine to give 50 and 52 by a side-chain substitution. This chemistry arose from facile defluorination of the anion radicals of 49 and 51. 

Diethylaminosulfur trifluoride Sulfur, (diethylaminato)trifluoro- (9) (38078-09-0) Fluoromethyl phenyl sulfide Benzene, [(fluoromethyl)thio]- (9) (60839-94-3)... 

Bromo-3,4,5-trifluorobenzene Benzene, 5-bromo-1,2,3-trifluoro- (13) (138526-69-9) Trimethyl borate Boric acid, trimethyl ester (8,9) (121-43-7)... 

One of the checkers added both the dibromoethane and subsequently the ether solution of bis(trifluoro-methyl)bromobenzene via syringe through a rubber septum stopper in place of the addition funnel. Filtration of the benzene solution removes unreacted starting material and other soluble impurities. +The tan solid obtained after drying by the benzene azeotrope procedure is much less soluble in CH2CI2 than the oily solid present before. 

The electrolysis of (trifluoromethyl)benzcne (1 g) in a solution of Et3N 3HF (6.7 g) in anhyd MeCN (25 mL), at a controlled potential of 3.2 V (SCE), with passage of 80% of the theoretical amount of charge, leads to the formation of 1-fluoro-3-(trifluoromcthyl)ben7.ene in 60% yield, while the passage of 170% of the theoretical amount of charge leads to the formation of a mixture of 1-fluoro-3-(trifluoro-methyl)benzenc (30%) and 1.3-difluoro-5-(trifluoromethyf)benzene (12%). 

Chlorine atoms in (trichloromethyl)benzenes which have fluoro, chloro, dichloromethyl, chloroformyl, cyano, isocyanato, jV-phthalimino or methyl substituents in the ring are substituted by fluorine using antimony(III) fluoride (Swarts reaction).3 4 2-(Trifluoromethyl)phen-yl isocyanate, 4-chloro-2-(trifluoromethyl)phenyl isocyanate, 2,4- and 2,5-bis(trifluoro-methyl)phenyl isocyanate, and 2,4-bis(trifluoromethyl)-l,5-phenylenc diisocyanate can be obtained in this way.5... 

Trichloromethyl)benzene and its derivatives are easily fluorinated with antimony(III) fluoride however, with a trifluorosilyl group in the 2-position, the use of antimony(V) chloride catalyst is required. Trifluoro[2-(trifiuoromethyl)phenyl]silane (6) can be prepared by this procedure in 87% yield.80... 

Perfluoro(l,3-dimethylbenzene) and sodium methoxide yield, depending on the amount of the nucleophile used, l,2,4-trifluoro-6-methoxy-3,5-bis(trifluoromethyl)benzene (19) or 1,4-di-fluoro-2,6-dimethoxy-3,5-bis(trifluoromethyl)benzene (20).94... 

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