Benzaldehyde Isocarboxazide

Warfarin sodium Benzal acetophenone Alkofanone Benzaldehyde Butalamlne HCI Chloramphenicol Fenipentol Isocarboxazid Oxacillin sodium Penicillin G benzathine Phenylpropanolamine HCI Tripelennamine Benzaldehyde cyanohydrin Ethotoin... 

Isocarboxazid Isocarboxazid, 2-benzylhydrazid-5-methyl-3-isoxazolecarboxylate (7.2.6), can be synthesized from acetylacetone, which on nitrosation with nitrous acid gives 5-methyl-isoxazol-3-carboxyhc acid (7.2.2). Esterification of this product gives the ethyl ester of 5-methyl-isoxazol-3-carboxyhc acid (7.2.3). The synthesized ester (7.2.3) is further reacted with benzylhydrazine, to give isocarboxazide (7.2.6), or with hydrazine, which forms 5-methyl-isoxazol-3-carboxylic acid hydrazide (7.2.4). Reacting the latter with benzaldehyde gives hydrazone (7.2.5), which is further reduced to the isocarboxazide (7.2.6) [46,47]. 

Isoniazide, the hydrazide of pyridine-4-carboxylic acid, is still, well over half a century after its discovery, one of the mainstays for the treatment of tuberculosis. Widespread use led to the serendipitous discovery of its antidepressant activity. This latter activity is retained when pyridine is replaced by isoxazole. The requisite ester (45-4) is obtained in a single step by condensation of the diketo ester (45-1), obtained by aldol condensation of acetone with diethyl oxalate, with hydroxylamine. One explanation of the outcome of the reaction assumes the hrst step to consist of conjugate addition-elimination of hydroxylamine to the enolized diketone to afford (45-2) an intermediate probably in equilibrium with the enol form (45-3). An ester-amide interchange of the product with hydrazine then affords the corresponding hydrazide (45-5) reductive alkylation with benzaldehyde completes the synthesis of isocarboxazid (45-6) [47]. 

C7H6() 100-52-7) see Acetorphan Amphetaminil Atorvastatin calcium Azimilide hydrochloride Benzathine benzylpenicillin Docetaxel L(-)-Ephedrine Ethotoin Fenipentol Fenquizone Furazolidone Imolamine Isocarboxazid Metamizole sodium Oxacillin Paclitaxel Phensuximide Phentermine Pildralazine Propiverine benzaldehyde [6-[(2-hydroxypropyl)methylamino]-3-py-ridazinyl]hydrazone... 

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