Benefits of Roller Compaction

This chapter briefly identifies key aspects of roller compaction technology. Unlike the slugging proeess technology, roller compaction technology is well suited for dry granulation agglomeration in the era of modern development of active pharmaceutical ingredients in pharmaceutical plants. 

Simplifies proeessing Facilitates powder flow Uses minimal energy to operate Requires less man-hours to operate Improves drug dosage weight eontrol Reproduces consistent particle density Produces good tablet and eapsule disintegration 

Uses less raw materials Eliminates water-induced degradants Improves process cycle time Prevents particle segregation Facilitates continuous manufacturing Improves content uniformity Does not require explosion proof room/ equipment 

When powder granules undergo an applied force or stress, a stress force is released from the granules. The granules attempt to return to their original shape or form this is described as elastic deformation. A deformation that does not totally recover after the stress is released is a plastic deformation. Elastic and plastic deformations can occur simultaneously, but one effect usually predominates. 

Dehont et al. developed Eq. 5.1 for the linear variation of flake thickness at a specific roll diameter (16)  

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