Bendroflumethiazide

Chemical Name 3,4-dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 

Trade Nama Manufacturer Country Year Introduced 

ICj Preparation of 3-Bemyl-6-Trifluoromethyl-7-Sulfamyl-3,4-Dihydro-1, 4 Ben othiadiazine 1,1-Dioxide A grams of 5-trifluoromethyl-2,4-disulfamylaniline is dissolved in 12 ml of dioxane. 2.7 ml of phenylacetaldehyde and a catalytic amount of p-toluenesulfonic acid are added. After boiling for a short time under reflux, the reaction mixture crystallizes, and, after filtration and recrystallization from dioxane, the desired product is obtained with a MP of 224.5°-225.5 C, 

IDI Alternative to (Cj—Q. grams of 5-trifluoromethyl-2,4-disulfamylaniline and 4.9 grams of oj-ethoxystyrene are dissolved in 35 ml of n-butanol. 0.5 grams of p-toluenesulfonic acid is added, and the mixture is heated on a steam bath while stirring. When the solution is clear, 55 ml of hexane is added, whereafter the mixture is heated further for one and a half hours. After cooling, the substance identical to that of Example (C) is filtered off and has a MP of 222°-223°C. 

Sterile compositions containing Bendroflumethiazide for parenteral administration may be prepared as described in U.S. Patent 3,265,573. 

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Ketanserin (25) is an antihypertensive agent acting as an antagonist at both the serotonin-S2 and Qj-adrencrgic receptors [22]. Bendroflumethiazide (26) is the most notable in a class of diuretic-antihypertensive agents [5]... 

Metatensin Tablets—trichlormethiazide, reserpine Minizide—polythiazide, prazosin Prinzide—hydrochlorotliiazide, lisinopril Rauzide Tablets—rauwolfia, bendroflumethiazide Regroton—chlorthalidone, reserpine Salutensin Tablets—hydroflumethiazide, reserpine Salutensin-Demi—hydrochlorothiazide, reseqiine Ser-Ap-Es—hydrochlorotliiazide, reseqiine, hydralazine HC1... 

C1H03S 7790-94-5) see Actinoquinol Azosemide Bendroflumethiazide Clopamide Diclofenamide Diethylstilbestrol disulfate Dorzolamide Furosemide Glibenclamide Glimepiride Hydroflumethiazide Lomoxicam Mafenide Meticrane Metolazone Saccharin Sildenafil Sodium picosulfate Sulfanilamide Tiotixene Tripamide Xipamide... 

C )H,20 17655-74-2) see Bendroflumethiazide (6/ -/ra/is)-3-[[(ethoxythioxomethyl)thio]methyl]-8-oxo-7-[(2-thienyla etyl)amino]-5-tbia-l-azabicyclo(4.2.0]oct>2-ene-2-carboxylic acid (4-nUrophenyl)methyl ester (C24H23N3O7S4) see Cefaclor... 

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