Belladonna dosage

Solanum Dulcamara Common Names Bittersweet, Climbing Nightshade, Deadly Nightshade, Felonwood, Mad Dog Berries, Violet Bloom Poison Belladonna Dosage 4-5 Berries, 8-i2/ioz(28G) Leaves... 

Adults 50 to 100 mg. Hydroxyzine may potentiate concomitant narcotics and barbiturates reduce dosages accordingly. Atropine and other belladonna alkaloids may be given as appropriate. 

Atropine, an alkaloid from Atropa belladonna, is the classical parasympatholytic compound. It competes with acetylcholine for the binding at the muscarinic receptor. Its affinity towards nicotinic receptors is very low, so that it does not interfere with the ganglionic transmission or the neuromotor transmission, at least in therapeutic dosages. However, in the central nervous system muscarinic receptor do play an important role and while atropine can penetrate the blood-brain barrier it exerts pronounced central effects. Atropine, like all other antagonists of the muscarinic acetylcholine receptor inhibit the stimulatory influence of the parasympathetic branch of the autonomous nervous system. All excretory glands (tear, sweat, salivary, gasto-intestinal, bronchi) are... 

Liquid oral antidiarrhoeals or any other dosage form for paediatric use containing diphenoxylate or atropine or belladonna including their salts and esters or metabolites, hyoscyamine or their extracts or their alkaloids. 

Atropine is contraindicated for patients who are hypersensitive to the belladonna alkaloids, have open-angle or angle-closure glaucoma, or have a tendency toward lOP elevations. Manufecturers recommended dosages should not be exceeded, particularly in infants, small children, and the elderly. Children with Down s syndrome demonstrate a hyperreactive pupillary response to topical atropine. 

The deliberate or accidental ingestion of natural belladonna alkaloids is a major cause of poisonings. Many histamine Hj-receptor antagonists, phenothiazines, and tricyclic antidepressants also block muscarinic receptors, and in sufficient dosage, produce syndromes that include features of atropine intoxication. 

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