Behavior prepulse

Attentional or cognitive impairments have also been observed in rodent models of nicotine withdrawal. These include impaired performance of a test of sustained attention (Shoaib and Bizarro 2005), disrupted contextual fear conditioning (Davis and Gould 2007 Davis et al. 2005), disrupted operant behaviors (Vann et al. 2006), and decreased prepulse inhibition, a test of selective attention (Semenova et al. 2003). 

Behavioral analyses Prepulse inhibition (PPI) ND Strong deficits Weak deficits ND... 

The nonspecific behavioral model paradigm is by prepulse inhibition that detects many antipsychotic drugs but also other drugs. 

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