Inflammatory response basophils

Immunoglobulin receptors, such as the high affinity receptor for IgE, are present on mast cells and bloodbome basophils. These receptors play an important role in hypersensitivity and the initiation of acute inflammatory responses. 

Histamine is one of the first inflammatory mediators that was considered to be important in the pathophysiology of a number of allergic diseases. Histamine is released from basophils and mast cells during hypersensitivity reactions to allergens and, -through activation of different receptor subtypes-, may provoke opposite effects on immune and inflammatory responses. While many of the inflammatory effects of histamine are mediated by Hi receptors, H2 receptors may mediate different immunomodulatory responses. This topic was extensively reviewed by Plaut and Lichtenstein (1982) and Falus (1994). 

Rdle of Mast Cells and Basophils in Inflammatory Responses 55... 

Allergens attach to mast cells and basophils in connective tissues, causing an antigen-antibody reaction. Mast cells stimulate the release of chemical mediators that constrict the bronchi, increase mucous secretions, stimulate the inflammatory response, and cause pulmonary congestion. 

The PMN cells include neutrophils, eosinophils, and basophils. Neutrophils make up 60-75% of circulating WBCs and provide the first line of defense against microbes that penetrate the normal barriers of skin. They are extremely efficient phagocytes and are a source of inflammatory cytokines and lipid mediators such as PGs, LTs, and platelet-activating factor. Eosinophils are involved in allergy and provide protection against parasites. Basophils contain vasoactive amines such as histamine, serotonin, and heparin, as well as precursors for PGs and LTs. Release of these pharmacological materials by the basophils is responsible for the anaphylactic reaction. These factors also serve as chemoattractants for neutrophils and eosinophils to sites of inflammation. 

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