Basophilic lesions

A single shallow, flat, non-bleeding gastric ulcer in the pre-pyloric region was reported in a 61-year-old male with end-stage kidney disease. Basophilic, nonpolarisable, rhomboid-like oystals were found by histopathology of the lesion [97 ]. A 52-year-old male patient treated for... 

This form of urticaria is usually due to an IgE-mediated reaction causing the release of biologically active factors from basophils and mast cells (Table 3). The initial response, occurring within minutes, is erythema caused by dilation of small blood vessels in the dermis. The wheal accompanying the erythema is due to increased capillary permeability causing transudation of fluid. Histamine is the major mediator involved in urticaria. Indeed, intradermal injection of histamine, as positive control for allergen skin prick tests, produces a wheal-and-flare response with pruritus similar to the urticarial lesions. Histamine is produced mainly by mast cells but also by basophils (73). 

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