Basics of Quantification Methods for Bioprocesses

Quantitative treatment is possible only for variables that are measurable. Such variables should be easily, reliably, and rapidly measurable in practice. Further, the variables measured should be key variables. The future development of measuring instrumentation will certainly bring further progress in this area. In practice, data collection is still dominated by the process variables listed in Table 2.1. 

The quantitative treatment of such a simplified process scheme with six variables is derivable from the following gross equation with stoichiometric 

THE MACROSCOPIC PRINCIPLE with CELLS as BLACK BOXES  

X Biomass Cell dry weight, turbidity, cell number 

S Substrates Enzymatic analyses—global methods (e.g. biological, chemical oxygen demand) 

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Basics of Quantification Methods for Bioprocesses 19 Table 2.1. Conventional process variables and their measurements. 

Basics of Quantification Methods for Bioprocesses 29 Table 2.4. Summary of macroscopic yield coefficients in bioprocessing. ... 

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