Basics of Fluorous Chemistry

On reaching the stage of fluorous separation, three methods are usually used for the rapid separation of fluorous compounds from the reaction mixture fluorous hquid-phase extraction, fluorous solid-phase extraction [6], and fluorous HPLC [7]. 

Fluorous separation is based on the fact that fluorophilic molecules have an affinity for fluorous media under certain condition, while non-fluorous ones do not have such affinity. Fluorous media can differentiate such affinity, therefore, can rapidly separate fluorous compounds from the rest The choice of the method depends on the nature of the components in the mixture to be separated and the purpose of the synthesis. 

Reaction mixture after filtration and diluted with water 

Second, for fluorous compounds with lower fluorine contents (less than 21 fluorines or F% 60%, light fluorous compounds), fluorous liquid-phase extraction is no longer effective. Fluorous solid-phase extraction selectively retains the fluorous components in the fluorous absorbent but does not retain the non-fluorinated 

fluorous HPLC is able to separate fluorous compounds from each other by decoding the fluorine content diflerences between fluorous compounds. The difference between FSG-based sohd-phase extraction and chromatography lies in the loading level of the samples. At a low loading level, the resolution of fluorous components increases and, therefore, multiple fractions with different fluorine contents can be collected as different components that is, fluorinated components 

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Chapters 1 and 2 have been reorganised and updated in line with recent developments. A new chapter on the Future of Purification has been added. It outlines developments in syntheses on solid supports, combinatorial chemistry as well as the use of ionic liquids for chemical reactions and reactions in fluorous media. These technologies are becoming increasingly useful and popular so much so that many future commercially available substances will most probably be prepared using these procedures. Consequently, a knowledge of their basic principles will be helpful in many purification methods of the future. 

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