Basement membranes isoforms

Figure 1. The muscle dystrophin-glycoprotein complex. The dystrophin-glycoprotein complex normally spans the plasma membrane of the skeletal muscle cell and may stabilize the sarcolemma and cytoskeleton to allow force transduction between the intracellular cytoskeleton (F-actin filaments) and the extracellular matrix. The molecules indicated are core components of the dystrophin-glycoprotein complex. Laminin 2 is the predominant laminin isoform in skeletal muscle basement membranes. Modified from McNeil and Steinhardt (2003)...

Laminin [consisting of three polypeptide chains, A, Bl (possibly replaced in GBM by S) and B2] is the most important noncollagenous protein of the glomerular basement membrane. Laminin forms a second network, which is connected to the collagen IV network probably via another protein called entactin or nidogen. Laminin is probably very important for cellular differentiation and adhesion, but its mesh clearly also contributes to the structure of the glomerular basement membrane. The postnatally common embryonic laminin-10 isoform is... 

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