Baseline diene conjugation

In bronchitics, there have been reports of elevated serum-conjugated dienes, hydroperoxides and aldehydes, and a claim of clinical eflicacy as well as normalization of these parameters after vitamin E therapy (Kleiner et al., 1990). However, these patients were given combined therapy including steroids and thus the effect of vitamin E alone cannot be assessed. N-Acetylcysteine administered to chronic bronchitics increased plasma cysteine from a below-normal baseline but it has not been shown that this intervention had any effect on the disease process, the dosing being of short duration, nor were there short-term effects of the release of ROS from blood neutrophils (reviewed by MacNee et al., 1991). A... 

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