Basal acid output

Omeprazole administered i.v. (0.5 mg/kg once daily) had a pronounced effect on basal acid output and gastric pH within 2h of administration, and basal and pentagastrin-stimulated acid output were significantly inhibited 24 h after the fourth consecutive dose (Jenkins et al 1992b). 

The growth in endoscopic procedures, with direct visualization of the interior of the stomach, has largely removed the need for the clinical laboratory to carry out the analysis of gastric contents. Situations remain, however, in which the laboratory continues to play a significant role in the diagnosis of gastric diseases and in monitoring the effectiveness of treatment. This section describes peptic ulcer disease and tests for Helicobacter pylori H. pylori) and the measurement of basal acid output from the stomach. 

Figure 48-5 Basal add output in healthy volunteers and patients with duodenal ulcers (DUs) of varying H pylori status ( , H pylori positive). Compared with H. pylori-negative healthy volunteers, basal acid output is increased in H py/or/-positive healthy volunteers P < 0.05), H py/orf-positive patients with DUs (P< 0.0001), and patients with DUs I month after eradication (P<0.0l). (From El-Omar EM, Penman ID,Ardill JES, Chittajallu RS, Howie C, McCoIl KEL H. pylori infection and abnormalities of acid secretion in patients with duodenal ulcer disease. Gastroenterology 1995 109 681 91, with permission from the American Gastroenterological Association.)...

Basal acid output (BAO) An estimate of the resting, unstimulated acid secretion is defined as the sum of the acid output from the gastric aspirate obtained over four consecutive I5-min periods. Table 2 shows... 

Upper and lower limits of normal (95% confidence limits) were derived from data obtained from 100 healthy men and 50 healthy women. There were no lower limits of normal for BAO or for the ratio of BAO to PAO because many normal subjects have a BAO of zero. BAO, basal acid output MAO, maximal acid output PAO, peak acid output. (Reprinted with permission from Feldman M (1989) Gastric secretion in health and disease. In Sleisenger MH and Fordtran JS (eds.) Gastrointestinal Disease Pathophysiology, Diagnosis, Management, vol. I, pp. 713-734. Philadelphia W.B. Saunders Company.)... 

Serum Pgl Basal Acid Output Peak Acid Output... 

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