Bartoli

Aloru, S., Bartoli, P., Leoni, M. and Memmi, M,. In Proc. Ini. Deep Drawing Research Group Conference. Amsterdam, Netherlands, 1985, Hoogoven IJmuiden BV, Paper 19. Davis, G.D, Groff, G.B., Biegert, L.L, and Heaton, H, J. Adhes., 54, 47 (1995). 

Both the Edwards equation and Pearson s HSAB concept take as primary determinants of nucleophilicity the polarizability and basicity. A two-term equation of Bartoli and Todesco" uses these ideas also, but as a measure of polarizability the... 

In 1989, Bartoli reported that vinylmagnesium bromide reacted with 2-nitrotoluene (4) at -40 C in THF to furnish 7-methylindole (5) in 67% yield. The reaction process also proceeded well with other 2-substituted nitrobenzenes. However, the 3- or 4-substituted nitrobenzenes provided either no indole products or indoles in poor yield. ... 

The Bartoli process has been employed effectively in the synthesis of 7-substituted indoles including 7-alkoxy (15), 7-alkyl (18) , and 7-formal indoles (21). Although the yields are only moderate, this process does provide a simple entry into indoles which were heretofore difficult to obtain. 

Recently, the Bartoli indole synthesis was extended to solid supports. In contrast to the earlier reports in the liquid phase, o,o-unsubstituted nitro analogs (see 25) prove to be useful substrates. In addition, fluoro/chloro substituted nitro derivatives are well tolerated, which typically undergo nucleophilic substitution under Bartoli conditions in the liquid phase. 

Despite these significant results in azide additions, only limited success has been obtained in enantioselective addition of other sp2-hybridized nitrogen-centered nucleophiles to meso-epoxides. Bartoli et al. demonstrated that aniline was a... 

Bartoli recently discovered that by switching from azide to p-anisidine as nucleophile, the ARO of racemic trans- 3-substituted styrene oxides could be catalyzed by the (salen)Cr-Cl complex 2 with complete regioselectivity and moderate selectivity factors (Scheme 7.36) [14]. The ability to access anti-P-amino alcohols nicely complements the existing methods for the preparation of syn-aryl isoserines and related compounds [67] by asymmetric oxidation of trans-cinnamate derivatives [68]. 

In sharp contrast, Bartoli showed that the (salen) Co catalyst system could be applied to the kinetic resolution of terminal epoxides with unprotected tert-butyl carbamate as nucleophile with extraordinarily high selectivity factors (Scheme 7.40) [72]. Excellent yields and selectivities are also obtained with use of ethyl, Cbz,... 

Bartoli F. J., Litovitz T. A. Raman scattering Orientational motion in liquids, J. Chem. Phys. 56, 413-25 (1972). 

Bartoli S, Bonora B, Colacci A, et al. 1991. DNA damaging activity of methyl parathion. Res Commun Chem Pathol Pharmacol 71 209-218. 

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