Bartoli indole synthesis applications

Although having been discovered only 20 years ago, the Bartoli indole synthesis has found more and more applications in indole and azaindoles synthesis. Applying the classic Bartoli conditions, nitropyridyl-piperazines were converted into 4-azaindole and 6-azaindole in 17 and 51% yield, respectively. Both azaindoles were prepared as potential S-HTe inhibitors for the indication of schizophrenia. 

Besides the general application in the preparation of 7-substituted indoles,Bartoli indole synthesis has found other applications, including the synthesis of azaindoles and optically pure 7-alkoxyltryptophan. ... 

Scheme 2 Gilmore Application of the Bartoli Indole Synthesis...

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