Ballooned hepatocytes

Fig. 21.4 Ballooned hepatocytes with intracellular bilirubino-stasis (— )...

Fig. 22.4 Feathery degeneration (arrows) of ballooned hepatocytes, massive liver cell oedema and bihrubinostasis in the cana-hculi. Clinically cholestatic course of acute viral hepatitis B...

FIGURE 36.9 (a) Synthetic AZA-1 (24 h) injured the liver and the small intestine. Erosion still be seen after 24 h (i), and characteristic change of late recovery at empty lamina propria can be seen in (ii). (b) Isomer injured the liver but ballooning hepatocytes appeared at central area, and did not injure small intestinal villi. 

In rats burned once with 29 or 100 mg/kg/day white phosphoms, an increase in ALT levels, necrosis, ballooning degeneration of hepatocytes, and microthrombi in the portal veins have been observed (Ben-Hur and Appelbaum 1973 Ben-Hur et al. 1972). In rabbits burned by white phosphoms (dose not reported), serum calcium and phosphoms levels were normal, and no morphological damage was observed (Bowen et al. 1971). No longer-term human and animal studies examining hepatic effects were found. 

Aoki M, Morishita R, Hayashi S, et al. Inhibition of neointimal formation after balloon injury by cilostazol, accompanied by improvement of endothelial dysfunction iand induction of hepatocyte growth factor in rat diabetes model. Diabetologia 2001 44 1032-1042. 

Protein storage Protein storage in the cytoplasm of the fiver cell is caused by antisecretory action, probably in the area of the microtubular system and the Golgi complex. This results in a ballooning of the hepatocytes. (s. p. 395) Alcohol-induced hepatomegaly is therefore due to the concurrence of hepatocellular protein and lipid storage and fiver cell hydropsy this can lead to a... 

A 67-year-old man with Sjogren s sjmdrome took cyclophosphamide for 2 years, a cumulative dose of 40.5 g. He then developed severe progressive jaundice due to acute hepatocellular injury. Gallstones and acute viral hepatitis were excluded, and only anti-smooth muscle antibodies were weakly positive. Liver histology showed marked ballooning of the hepatocytes and cell loss, cytoplasmic and canahcular cholestasis, and infiltration of the portal tract with inflammatory cells. Complete resolution occurred 6 weeks after cyclophosphamide withdrawal. 

A 46-year-old woman developed fatigue and jaundice about 20 weeks after she started to take nefazodone (300 mg/day). She had raised liver enzymes and bilirubin concentrations. There was no evidence of infectious hepatitis or immune disorders. Liver biopsy showed ballooning degeneration and necrosis of hepatocytes with mixed inflammatory infiltrates. The nefazodone was withdrawn and corticosteroid treatment started. Within 4 months she recovered clinically and her liver function tests returned to normal (11). 

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