Cyclosporine Balkan nephropathy

Balkan nephropathy is non-destructive and noninflammatory tubulointerstitial renal disease [69]. The changes are non-specific and in the chronic, sclerotic phase they may be quite similar to changes observed in other chronic interstitial diseases such as analgesic nephropathy [70], vascular nephrosclerosis [69] cyclosporine-induced nephropathy [71], radiation nephritis [72,73] and aging [72], intoxication with silicate, cadmium, lead, uranium [74], mycotoxin ochratoxin... 

Interlobular capillaries are filled with thick, proteinaceous substances that are also deposited below the capillary endothelium and may even be found free in the interstitium. These changes are described as capillary sclerosis [68]. Although renal vascular changes in Balkan nephropathy have been pointed out as very important, they are not specific and can be encountered in other renal diseases. Ferluga et al. [70] and Sindjic [77] point out to similarities in early changes encountered in Balkan nephropathy with cyclosporine-induced nephrotoxic changes. 

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