Bacterium thermo

The use of the thermophilic bacterium Thermo an aerobium brockii leads to the same product in 50-80% yield and 72% ee"3. 

The thermal stability of thermolysin, a peptidase from the thermo-phillic bacterium Bacillus thermoproteolyticus, is apparently conferred by calcium bound to the enzyme (194), which has a molecular weight of 35,000 (195), and binds one mole of zinc (195) and three moles of calcium per mole of protein (196). Thermolysin contains no non-protein constituents (197) and consists of a single peptide chain containing neither cysteine nor cystine (197). Thermolysin has a high content of aspartic... 

The most interesting new polyterpenoids are a series of C40 diols that form part of macrocyclic diglycerol tetraethers which constitute the major membrane lipids of the extremely thermo- and acido-philic bacterium Caldariella. These compounds, (196)—(200), which may be acyclic or may have from one to four isolated cyclopentane rings are formally dimers of C20 isoprenoid structures linked head-to-head rather than the conventional tail-to-tail linkage in, for example, carotenoids.The isoprenoid nature of these compounds has been shown by labelling. 

Kerfai S, Fernandez A, Mathe S, Alfenore S, Arlabosse P (2011) Production of green juice with an intensive thermo-mechanical fractionatirai process. Part II effect of processing conditions on the liquid fraction properties. Chem Eng J 167(1) 132—139. doi 10.1016/j.cej.2010.12.011 Kim B-C, Grote R, Lee D-W, Antranildan G, Pyun Y-R (2001) Thermoanaerobacter yonseiensis sp. nov., a novel extremely thermophilic, xylose-utilizing bacterium that grows at up to 85 °C. Int J SystEvol Microbiol 51(4) 1539-1548... 

The metalloprotease thermolysin has been widely used for peptide synthesis [66,67]. Thermolysin is produced and secreted by the thermophilic bacterium Bacillus thermo-proteolyticus. Catalysis involves water activation by a zinc ion that is coordinated by side chains of two histidines and a glutamate. Thermolysin specificity is defined by its Sr pocket accepting large hydrophobic, polar, and charged residues. In the SI pocket hydrophobic residues are preferred, and Leu > Ala > Phe > Gly is the preference order for the S2 and S2 pockets. This hydrolytic specificity of thermolysin is reflected in its synthetic specificity. 

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