Bacterial transporters

Fig. 5. A simple kinetic representation of a transport reaction catalyzed by a bacterial transport protein. Ecyt, and Eper denote those conformations of the enzyme with the binding site facing the cytoplasm and periplasm, respectively.

Hyde, S.C., Emsley, P., Hartshorn, M.J., Mimmack, M.M., Gileadi, U., Pearce, S. R., Gallagher, M.P., Gill, D.R., Hubbard, R.E. and Higgins, C.F. (1990) Structural model of ATP-binding proteins associated with cystic fibrosis, multidrug resistance and bacterial transport. Nature, 346, 362-365. 

Matrix pore size of >10 p.m, permitting bacterial transport... 

Although the above studies conducted with packed columns are important from a fundamental standpoint as they relate to the mechanisms of cell sorption to solid surfaces, in situ remediation of contaminants in subsoils requires microbial transport in well-structured soils. The presence of soil macropores that facilitate preferential water flow is well appreciated (Thomas Phillips, 1979). Sorption phenomena are less important when bacterial transport occurs through structured soils in which cells pass unimpeded through relatively large conduits (Smith et al., 1985). 

Gannon, J.T., Mingelgrin, U., Alexander, M. Wagenet, R. J. (199lb). Bacterial transport through homogenous soil. Soil Biology Biochemistry, 23, 1155-66. 

Bajjalieh SM, Peterson K, Shinghal R, Scheller RH (1992) SV2, a brain synaptic vesicle protein homologous to bacterial transporters. Science 257 1271-1273. 

Chen CJ, Chin JE, Ueda K, et al. Internal duplication and homology with bacterial transport proteins in the mdrl (P-glycoprotein) gene from multidrug-resistant human cells. Cell 1986 47(3) 381-389. 

Gros P, Croop J, Housman D. Mammalian multidrug resistance gene complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell 1986 47(3) 371-380. 

Rudnick G (2007) What is an antidepressant binding site doing in a bacterial transporter ACS Chem Biol 2 606-609... 

Adapted from Table 1 in Hancock REW. Bacterial transport as an import mechanism and target for antimicrobials. In Georgopapadakou NH, ed. Drug transport in antimicrobial and anticancer chemotherapy. New York Marcel Dekker, Inc. 1995. p. 289G306. 

Relatively few membrane transport proteins have been structurally characterized. Some of the best understood examples to date are the lactose permease and glycerol-3-phosphate transporter and the Ca + P-type ATPase (which is a primary ion pump). Other structurally well-characterized transport proteins include the bacterial porins and siderophore receptor proteins. In addition structures have been determined for several ion channels and additional bacterial transporters that are either directly relevant to or models for proteins important in drug transport. The following web sites maintained by Hartmut Michel and Stephen White respectively, contain exceptionally useful listings of these and other solved membrane protein structures and are frequently updated ... 

This chapter focuses on the environmental implications of sediments mobilized in response to rain events. Three different aspects are discussed the role of suspended sediment in bacterial transport, temporal changes in sediment geochemistry, and... 

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