Bacterial multidrug transporter

Ubarretxena-Belandia I, Baldwin JM, Schuldiner S, Tate CG. Three-dimensional structure of the bacterial multidrug transporter EmrE shows it is an asynunetric homodimer. EMBO J. 2003 22 6175-6181. 

Neyfakh A. Natural functions of bacterial multidrug transporters. Trends Microbiol. 1997 5 309-313. 

Serysheva II, Ludtke SJ, Baker MR, Chiu W, Hamilton SL. Structure of the voltage-gated L-type Ca2+ channel by electron cryomi-croscopy. Proc. Natl. Acad. Sci. U.S.A. 2002 99 10370-10375. Ubarretxena-Belandia I, Baldwin JM, Schuldiner S, Tate CG. Three-dimensional structure of the bacterial multidrug transporter EmrE shows it is an asymmetric homodimer. EMBO J. 2003 22 6175-6181. 

Bacterial Multidrug Transporters Molecular and Clinical Aspects... 

Murakami, S., Nakashima, R., Yamashita, E. and Yamaguchi, A. (2002). Crystal structure of bacterial multidrug efflux transporter AcrB, Nature, 419, 587-593. 

Dawson RJ, Locher KP. Structure of a bacterial multidrug ABC transporter. Nature 2006 443 180-5. 

An enormous amount of information on bacterial efflux transporters has been summarized in several recent excellent review articles, addressing various aspects of the efflux problem, such as the origin and evolution of efflux pump [16], mechanisms of multidrug recognition [10,17], regulation of expression of MDR pumps [18-20], natural functions of MDR pumps [21], and clinical aspects of MDR [22-24]. 

Mehmood, S., Domene, C., Forest, E., Jault, J.-M. (2012) Dynamics of a bacterial multidrug ABC transporter in the inward and outward facing conformations. Proceedings of the National Academy of Sciences of the United States of America, 109 (27), 10832-10836. 

Substrate for bacterial ABC transporters (287,300,301) reversal of multidrug resistance in methicillin-resistant Staphylococcus aureus (MRSA) strains (NorA MDR pump) P-gp substrate... 

Sakamoto, K., Margolles, A., van Veen H.W., and Konings, W.N. (2001) Hop resistance in the beer spoilage bacterium Lactobacillus brevis is mediated by the ATP-binding cassette multidrug transporter HorA. J Bacterial 183, 5371-5375. 

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