Bacillus subiilis

A toxicological study of the methanolic extract of M. grandiflora heartwood led to the identification of menisperine (N-methyl isocorydine) (38), a phenolic quaternary alkaloid [62]. Toxicity of this methanol extract was ultimately due to the neuromuscular blocking action of the alkaloid. Davis isolated this alkaloid and two antibacterial compounds, parthenolide (1) and anonaine (39), from M grandiflora [63]. Parthenolide, from the yellowed leaves of M. grandiflora exihibited antibiotic activity against Bacillus subiilis at an MIC (minimum inhibitory concentration) of 3 Xg ml 1. Anonaine demonstrated antibacterial activity at 100 mg ml against... 

Subtilisin (see) from Bacillus subiilis is a S.p. it resembles chymotrypsin in the hydrogen bonding of the charge-relay system, but is otherwise structurally dissimilar it is thus an example of convergent evolution of a catalytic center in two different groups of proteins. 

Hahn J. Kong L, Dubnau D. The regulation of competence transcription factor synthesis constitutes a critical control point in the regulation of competence in Bacillus subiilis. J BaC teriol 1994 176 5753-5761. 

Kong L, Siranosian KJ, Grossman AD, Dubnau D. Sequence and properties of mecA A negative regulator of genetic competence in Bacillus subiilis. Mol Microbiol 1993 9 365-373. 

Marahiel MA, Zuber P, Czekay C, Losick R. Identification of the promoter foi a peptide antibiotic gene from Bacillus brevis and studies on its regulation in Bodllus subiilis. ] Bacteriol 1987 169 2215-2222. 

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