Bacampicillin Chloroquine

Clinically important, potentially hazardous interactions with acitretin, aldesleukin, aminoglycosides, amiodarone, amoxicillin, ampicillin, aspirin, bacampicillin, bismuth, carbenicillin, chloroquine, cisplatin, cloxacillin, co-trimoxazole, dapsone, demeclocycline, dexamethasone, diclofenac, dicloxacillin, etodolac, etoricoxib, etretinate, fenoprofen, flurbiprofen, folic acid antagonists, haloperidol, hydrocortisone, ibuprofen, indomethacin, influenza vaccines, ketoprofen, ketorolac, lithium, magnesium trisalicylate, meclofenamate, mefenamic acid, methicillin, mezlocillin, minocycline, nabumetone, nafcillin, naproxen, NSAIDs, omeprazole, oxacillin, oxaprozin, oxytetracycline, paromomycin, penicillin G, penicillin V, penicillins, phenylbutazone, piperacillin, piroxicam, polypeptide antibiotics, prednisolone, prednisone, probenecid, procarbazine, rofecoxib, salicylates, salsalate, sapropterin, sulfadiazine, sulfamethoxazole, sulfapyridine, sulfasalazine, sulfisoxazole, sulindac, tazobactum, tenoxicam, tetracycline, ticarcillin, tolmetin, trimethoprim, vaccines... 

Chloroquine 1 g reduced the absorption (as measured by excretion in the urine) of a single 1-g dose of oral ampicillin by about one-third (from 29 to 19%) in 7 healthy subjects. Another study by the same author demonstrated that the absorption of ampicillin from bacampicillin tablets was unaffected by chloroquine. ... 

Information appears to be limited to the studies cited, which used large doses of chloroquine (1 g) when compared with those usually used for malarial prophylaxis (300 mg base weekly) or for rheumatic diseases (150 mg daily). The reduction in the ampicillin absorption is also only moderate. The general clinical importance of this interaction is therefore uncertain. However, one report suggests separating the dosing by not less than 2 hours. An alternative would be to use bacampicillin (an ampicillin pro-drug), which does not appear to interact with chloroquine. More study is needed to confirm and evaluate the importance of this interaction. 

Ali HM. The effect of Sudanese food and chloroquine on the bioavailability of ampicillin from bacampicillin tablets. IntJ Pharmaceutics (1981) 9,185-90. 

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See also in sourсe #XX -- [ ]

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