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Bacampicillin

Chemical Name 6-[(AminophenylacetyDamino] -3,3-dimethyl-7-oxo-4-thia-1 -azabicyclo-[3.2.0] heptane-2-carboxylic acid 1-[(ethoxycarbonyl)oxy]-ethyl ester [Pg.124]

Trade Name Manufacturer Country Year Introdi [Pg.124]

Sodium 6-(D-tt-azidophenylacetamido)penicill a-Chlorodiethyl Carbonate Sodium Bicarbonate Hydrogen [Pg.124]

1 -Ethoxycarbonyloxyethyl 6-(D-a-azidophenylacetamido)penicillinate (98 g) was prepared from sodium 6-(D-a-azidophenylacetamido]penicillinate (397 g, 1 mol), a-chlorodiethylcar-bonate (458 g, 3 mols) and sodium bicarbonate (504 g, 6 molsl. The product showed strong IR absorption at 2090 cm- and 1 780-1750 cm showing the presence of azido group and /3-lactam and ester carbonyls. [Pg.124]

Chemicai Name 6-[(Aminophenyi8cetvi)amino] -3.3-dimethyi-7-oxo-4-thia-1-azabicycio- [Pg.124]

The pharmacology of penicillins differs markedly from compound to compound but has been well reviewed (57). The majority of derivatives, including penicillin G and the antipseudomonal penicillins, ate unstable in gastric acid and ate not available orally. The isoxazolyl penicillins ate relatively acid stable but not consistendy well absorbed by the oral route. Nafcillin and oxacillin ate poody absorbed orally cloxacillin, dicloxacillin, and ducloxacillin ate more teUable. Penicillin V, ampicillin, and patticulady amoxicillin ate relatively well absorbed orally. Esters of ampicillin such as bacampicillin, pivampicillin, and talampicillin improve the level of oral absorption of ampicillin to that achieved by amoxicillin. Absorption can be diminished by food after oral adruinistration, however, and peak blood levels, usually achieved after 1 to 2 h, ate somewhat delayed after ingestion of food. [Pg.83]

Adequate blood levels of the drug must be maintained for die agent to be effective. Accidental omission or delay of a dose results in decreased blood levels, which will reduce the effectiveness of the antibiotic. It is best to give oral penicillins on an empty stomach, 1 hour before or 2 hours after a meal. Bacampicillin (Spectrobid), penicillin V (Pen-Vee K), and amoxicillin (Amoxil) may be given without regard to meals. [Pg.72]

Penicillin (oral)—Take the drug on an empty stomach either 1 hour before or 2 hours after meals (exceptions bacampicillin, penicillin V, amoxicillin). [Pg.73]

Women prescribed ampicillin, bacampicillin, and penicillin V who take birth control pills containing estrogen should use additional contraception measures. [Pg.73]

A 28-year-old married woman with three children is prescribed bacampicillin (Spectrobid) for an upper respiratory infection caused by Streptococcus pneumoniae. W hat information would be important for you to obtain from this woman What special instructions would you give her because of her gender and age ... [Pg.74]

C ,H jN5Na04S 35334-12-4) see Bacampicillin 17a-azido-3P,16a-diacetoxy-5a-pregnane-ll,20-dione (C25H35NtiO 5167-90-8) see Deflazacort Fluazacort 2-azido-7V-[2-(2,5-dimcthaxyphenyl)-2-oxoethyl]acetamide (C,2H,4N404 59939-34-3) see Midodrine 2-azidoethanol... [Pg.2300]

S Ehrnebo, O Nilsson, LO Boreus. Pharmacokinetics of ampicillin and its prodrugs bacampicillin and pivampicillin in man. J Pharm Biopharmacokin 7(5) 429-451, 1979. [Pg.230]

L Magni, J Sjovall, E. Vinnars. Bioavailability of bacampicillin and talampicillin. Antimicrob Agent Chemother 20(6) 837-838, 1981. [Pg.230]

Sjovall J, Sjoqvist R, Huitfeldt B, Nyqvist H. Correlation between the bioavailability of microencapsulated bacampicillin hydrochloride in suspension and in vitro microcapsule dissolution. J Pharm Sci 1984 73 141—145. [Pg.247]

L-Arginine [74-79-3] (8) Bacampicillin hydrochloride [37661-08-8] 302D I(1)786A, N(1)658B CF1934200, USP SH8490000, USP... [Pg.1050]

Rx amoxicillin, ampicillin, bacampicillin, carbenicillin, cloxacillin, dicloxacillin, flucloxacillin, methicillin, mezlocillin, nafcillin, oxacillin, penicillin G benzathine, penicillin G potassium, penicillin Vpotassium, piperacillin, pivampicillin, pivme-cillinam, ticarcillin Penicillin and beta-lactamase inhibitors amoxicillin/ clavulanate potassium, ampicillin/sulbactam sodium, piperacillin sodium/ tazobactam sodium, ticarcillin disodium/clavulanate potassium Chemical Class Penicillin, natural... [Pg.952]

Amoxicillin [Amoxil, Polymox, others] Ampicillin [Omnipen, Polycillin, others] Bacampicillin [Spectrobid] Extended-spectrum penicillins Carbenicillin [Geocillin, Geopen, Pyopen] Mezlocillin [Mezlan]... [Pg.504]

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