B2-microglobulin

Rat (Wistar) 2-4 mo ad lib (W) Renal 81 F 320 F (tubular dysfunction as indicated by 2-3-fold increase in urinary excretion of B2-microglobulin) Vyskocil et al. 1995 PbAc... 

The structure of MHC. In the context of antigen recognition by T cells, we are primarily concerned with class I and II MHC molecules. Class III MHC are essentially a part of the complement system. Class I molecules are made up of transmembrane heavy-chain peptide, which is noncovalently associated with the B2 microglobulin (B2m) molecule. Class II, on the other hand, is composed of two smaller transmembrane peptide chains, a and p. The peptides are arranged in domains that are of comparable size to those of the immunoglobulin molecules. 

Junghans, R P. and Anderson, C. L. (1996). The protection receptor for IgG catabolism is the b2-microglobulin-containing neonatal intestinal transport receptor. Proc. Natl. Acad. Sci. USA 93 5512-5516. 

The strong association between cortical quinolinic acid concentrations and local IDO activity supports the view that the induction of IDO is an important event in initiating the increase of quinolinic acid production (Heyes et al., 1992). In the CNS, invaded macrophages and microglial cells are able to produce quinolinic acid (Saito et al., 1993). Peripheral immune stimulation, however, under certain conditions also leads to increased CNS concentration of quinolinic acid (Saito et al., 1993). During a local inflammatory CNS process, the quinolinic acid production in the CNS increases without changes of the blood-levels of quinolinic acid. While the local quinolinic acid production correlates with the level of B2 microglobulin, an inflammatory marker. Local CNS concentrations of quinolinic acid are able to far exceed the blood levels (Heyes et al., 1998). 

Feder JN, Tsuchihaslii Z> Irrinid A, Lee VIC, Mapa FA, Morikang E, et al. The hemochromatosis founder mutation in HLA-H disrupts B2-microglobulin interaction and ceU surface expression. J Biol Chem 1997 272 14025-8. 

Waheed A, Parkkila S, Zhou XY, Tomatsu S, Tsuchi-hashi Z, Feder JN. Hereditary hemochromatosis effects of C282Y and H63D mutations on association with B2-microglobulin, intracellular processing, and ceE surface expression of the HFE protein in COS-cells. Proc Natl Acad Sci USA 1997 94 12384-9. 

Pappo AS, Douglass ED, Meyer WH, et al. Use of HBA 71 and anti-B2-microglobulin to distinguish peripheral nerrroepithelio-ma from neuroblastoma. Hum Pathol. 1993 24 880-885. 

---