Aziridination of Enones Using Cinchona-Based Chiral Phase-Transfer Catalyst

Aziridination of Enones Using Cinchona-Based Chiral Phase-Transfer Catalyst 

Aziridines are useful precursors for the preparation of biologically active species such as amino acids, P-lactams, and alkaloids [27]. Numerous stereoselective variants 

Entry R1 R2 Peroxide Temperature (C) Time (h) 23 24 Yield (%) ee (%) of major product 

As discussed above, the use of phase-transfer conditions has not usually provided satisfactory results for asymmetric aziridination reactions. Recently, Melchiorre and coworkers developed a highly versatile and efficient catalytic methodology for 

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