8- azapropazone

CK1H14N4 43171-03-5) see Azapropazone 2-dimethylamino-l-methyIethyl chloride see under l-dimethylamino-2-chloropropane... 

CjHf,N2 1467-79-4) see Azapropazone dimethyl cyanocarboimidodithioatc (C4HSN2S2 10191-60-3) see Cimetidine dimethyl cyclohexylidenemainnate (C11H14O4 94286-34-7) see Gabapentin (S )-2,2-dimethylcyclopropanecarboxamide (QH iNO 75885-58-4) see Cilastatin... 

Caron, G. Pagliara, A. Gaillard, P. Carrupt, P-A. Testa, B., Ionization and partitioning profiles of zwitterions The case of the anti-inflammatory drug azapropazone, Helv. Chim. Acta. 79, 1683-1695 (1996). 

Rheumatological drugs Allopurinol Azapropazone Phenylbutazone Other Disulflram Dextropropoxyphene... 

Treatment with COX-2 selective drugs has shown a lower likelihood of symptomatic ulcer or ulcer complications than treatment with non-selective NSAIDs, with non-selective NSAID risks varying dose-dependently and between drugs, with ibupro-fen lowest, and piroxicam and azapropazone amongst the highest. Whether COX-2 selective drugs pose no risk is unclear. 

Azapropazone Diazoxide Heparin Oral hypoglycemics Ticlopidine... 

Azapropazone, carprofen, meclofenamate, and tenoxicam are rarely used and are not reviewed here. 

The dioxopyrazolines are also acidic because of their enolic group (4,4-disubstituted analogues are inactive) and a recent example azapropazone (apazone) (184) inhibits prostaglandin synthesis. Its pharmacological properties are like those of phenylbutazone and it is also uricosuric. Anti-inflammatory 1,2-benzothiazine 1,1-dioxides such as piroxicam (185 R = 2-pyridyl) also have an acidic enolic group whose anion can be stabilized by... 

Fries-type rearrangements (Sch. 15) (36) also occur photochemically this is generally a homolytic process, in contrast to the ionic mechanism of the thermal process. Azapropazone undergoes photoinduced 1,3-acyl shift in the solid state and fragmentation in solution (Sch. 16) (37). 

Reisch J, Ekiz-Giicer N, Takacs M, Gunaherath GM, Kamal B. The photoisomerization of azapropazone. Arch Pharm (Weinheim) 1989 322 295-296. 

These drugs are available in many other countries but are not sold in the USA. Azapropazone (apazone), a pyrazolone derivative, is structurally related to phenylbutazone but appears less likely to cause agranulocytosis. Its half-life of 12-16 hours may be doubled in patients with decreased renal function. Carprofen is a propionic acid derivative with a half-life of 10-16 hours. The indications and adverse effects of azapropazone and carprofen are similar to those of other NSAIDs. 

Nonselective COX inhibitors derive from salicylic acid. The majority are carbonic acids, such as ibuprofen, naproxene, diclofenac, indometacin, and many more or enolic acids, such as azapropazone and meloxicam. All these drugs inhibit both COX enzymes. 

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