Axys Pharmaceuticals

The monofunctional tryptase inhibitor APC-366 (Axys Pharmaceuticals) reduces the acute airway response and histamine release to allergen in a pig model of allergen-induced asthma [19]. APC-366 is also effective in a sheep model of allergen-induced asthma but was only poorly effective in asthma patients (proof-of-principle) [8], The compound was in clinical development phase II for asthma (inhalative). Although highly selective for tryptase over plasmin and plasma kal-likrein, APC-366 was not selective against thrombin and trypsin [13], Another monofunctional tryptase inhibitor is bis(5-amidino-2-benzimidazol-yl)methane (BABIM) which has been shown to be effective in the sheep. Further development of the compound was, however, discontinued, maybe because of the lack of selectivity over trypsin [13, 16, 17] (Figure 3.2.2). 

Fig. 3.2.2. Two monofunctional tryptase inhibitors for inhalative application - APC 366 (Axys Pharmaceuticals) and BABIM.

Brooks-Wilson AR, Buckler A, Cardon L, et al Asthma related genes. US Patent Trademark Office 6,087,485. South San Francisco, AxyS Pharmaceuticals, 2000. (NC)... 

Amylin Pharmaceuticals, Inc. Andie Pharmaceuticals Angstrom Pharmaceuticals, Inc. Arena Pharmaceuticals, Inc. Argonaut Technologies, Inc. Athena Neurosciences, Inc. Axiom Biotechnologies Inc. AXYS Pharmaceutical Corp. Aurora Biosciences Corp. Bachem California, Inc. 

Asked what he thought the initial expectations for genomic data were, Dr Michael C. Venuti, former head of research at Arris (later Axys) Pharmaceuticals, and now CEO of BioSeek, put it wryly. I think everyone in biotech and pharma hoped that we would take out our secret decoder ring and there d be all kinds of things in there that would be obvious if we turned on our computers at the right time of day, he said. I think everyone eventually came to the realization that it s what everyone did with the information that matters, and it s still what anyone does with the information that matters. ... 

Figure 3.2 Example of a Markush structure and part of the description thereof. (From Prasit, et al., US 7,012,075 (to Merck Co. and Axys Pharmaceuticals).)...

Coutor (U.S. Patent 2,036,924, 1936). See also Eisenlohr [Ind. Chem., 27, 271 (1951) Chem. Jng. Tech., 23, 12 (1951) Phorm. Ind., 17, 207 (1955) Trans. Indian Inst. Chem. Eng., 3, 7 (1949-1950)] and Husain et al. [Chim. Ind. ( 4ilan), 82, 435 (1959)]. This centrifuge revolves about a vertical axis and contains three actual stages. It operates at 3800 r/min and handles approximately 4.92 mVh (1300 gaPh) total liquid flow at 12-kW power requirement. Provision is made in the machine for the accumulation of solids separated from the hquids, for periodic removal. It is used, more extensively in Europe than in the United States, for the extraction of acetic acid, pharmaceuticals, and similar produces. 

Klous MG, Nuijen B, van Den Brink W, van Ree JM Beijnen JH (2007). Pharmaceutical development of dosage forms of diamor-phine for use by heroin addicts. Pharma-ceutisch Weekblad, 142, 98-104 Kokkevi A, Stefanis N, Anastasopoulou E Kostogianni C (1998). Personality disorders in drug abusers prevalence and their association with AXIS I disorders as predictors... 

The V-mixer is a simple device, widely used in the pharmaceutical industry, which consists of two cylinders, joined at 90°, as shown in Figure 11 (Kuo et al., 2002, 2005). It rotates around the axis shown, thus, repeatedly dividing (a) and recombining (v) the charge. At each rotation a small amount of material is transferred across the plane of symmetry between the two arms. The reason for studying this device is not because it is of great inherent interest in itself but because it is... 

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