Dioxin intake, average daily

Average Daily Intake (ADI) via dietary exposure to dioxin-like compounds was estimated by multiplying residue concentrations and... 

For risk assessment purposes, an important objective in evaluating the environmental fate of PCDD/Fs is predicting the major pathways of human exposure. It is well established that the food chain, especially meat and dairy products, accounts for more than 90% of human exposure to PCDD/Fs and perhaps as much as 99% of human exposure to 2,3,7,8-TCDD.34 In industrialized countries, the average daily intake via food (the major route of exposure to dioxins and furans) ranges from 1.5 to 2.5 pg TEQ kg-1 body weight. 

Trace dioxins have been detected in soil, sediment, vegetation, fruits, fish and mammalian tissne, and bovine milk. 2,3,7,8-snbstitnted isomers and other polychlorinated dibenzo-p-dioxin and polychlorinated diben-zofurans have been detected in the snrface samples at many PCBs disposal facilities. The major source of human exposure to dioxin is the food chain. Dioxins bioaccumulate in adipose tissue in humans. According to an estimate, the long-term average daily intake of dioxin in humans is 0.05 ng/day (Hattemer-Frey and Travis 1987). 

Estimates of total daily intake of dioxin via food in industrialized nations are fairly consistent, ranging from 1.3 to 2.3 pg TEQ kg-1 d 1.14,42,43,62The average long-term intake of PCDD/Fs by the general population of the US is about 127 pg TEQ d with an intake of TCDD of about 27 pg d h... 

Let us assume that the average person now has a daily intake of 0.8 pg of dioxin per kg of body weight and that the average concentration of dioxin in that person is 0.7 ppt. What is dioxin s average half-life in people ... 

The daily intake of dioxin in industrial countries is estimated at 1-3 pg TEQ/kg body weight. The half life and the absorption rate are assumed to be 7.5 years and 50% respectively. In 1997, the WHO set a value of 1-4 pg TEQ per kg body weight and day as a tolerable, lifelong intake (tolerable daily intake, TDI). Table 9.18 shows the estimated dioxin intake with food. Due to the concentration of dioxins in the fat phase, mother s milk in the industrial countries has on average... 

---