Automation screening methods

In addition, it has to be taken into consideration that these automated screening methods can also be used for isotopic analysis just by replacing the spectrophotometer by a fraction collector and taking the fractions which contain the isolated and preconcentrated radionuclides to a detector which allows isotopic analysis when the reference value is smpassed. 

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Schmidt, M.A., Microfabricated chemical systems for product screening and synthesis, in Hoyle, W. (Ed.), Automated Synthetic Methods for Specialty Chemicals, pp. 14-24, Royal Society of Chemistry, Cambridge (2000). 

Yazbeck D, Tao J, Martinez C, Kline B, Hu S (2003) Automated enzyme screening methods for the preparation of enantiopure pharmaceutical intermediates. Adv Syn Cat 4 524-532... 

HO Friestad. Rapid screening method, including automated colorimetry, for low residue levels of lin-uron and/or chloropropham in vegetables. J Assoc Off Anal Chem 57 221-225, 1974. 

The development and innovation of the agricultural and food industry rely generically on two fundamental axes food safety and food quality. The more and more complexity of the food chain demands the development of efficient traceability systems which guarantee the firmness of all chain links. In this context, a clear priority is defined in the development of molecular methods of detection, analysis and diagnosis. These methods should be rapid, of high sensitivity and should permit automated screening. 

At the beginning of this chapter we will look into the different automated alignment methods as correct alignment is the first and most important prerequisite for a successful pharmacophore identification process. Further, we will elaborate how essential issues of pharmacophore modeling such as conformational search, pharmacophore feature definitions, compounds structure storage and screening are handled by various available software packages. 

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