Autoimmunity pristane

Kuroda et al. (2004) reported autoimmunity induced by adjuvant hydrocarbon oil components of some human and veterinary vaccines. This study showed that an injection of certain adjuvant hydrocarbon oils (pristane, incomplete Freund s adjuvant, or squa-lene) induced lupus-related autoantibodies to nuclear ribonucleo-proteins (nRNP)/Sm and Su in non-immune Balb/c mice. 

A few examples of animal models used in immunotoxicologic testing of drugs include Brown Norway rat and Lewis rat models, which are described in detail below. Other established mouse models of autoimmune diseases, e.g.,systemic lupus erythematosus, collagen-induced arthritis,pristane-induced arthritis and systemic scleroderma, may be considered for potential application in immunotoxicology evaluation. 

Odobasic, D., Muljadi, R. C., O Sullivan, K. M., etal. (2015). Suppression of autoimmunity and renal disease in pristane-induced lupus by myeloperoxidase. Arthritis and Rheumatism, 67(7), 1868-1880. 

A. Mizutani, V. M. Shaheen, H. Yoshida, J. Akaogi, Y. Kuroda, D. C. Nacionales, Y. Yamasaki, M. Hirakata, N. Ono, W. H. Reeves and M. Satoh, Pristane-induced autoimmunity in germ-free mice, Clin. Immunol., 2005, 114, 110-118. 

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