Mammals atrazine

Lethal and sublethal effects of atrazine on selected species of mammals... 

Table 11.7 Lethal and Sublethal Effects of Atrazine on Selected Species of Mammals Organism, Dose, and Other Variables Effect and Reference...

Egaas, E., J.U. Skaare, N.O. Svendsen, M. Sandvik, J.G. Falls, W.C. Dautennan, T.K. Collier, and J. Netland. 1993. A comparative study of effects of atrazine on xenobiotic metabolizing enzymes in fish and insect, and of the in vitro phase II atrazine metabolism in some fish, insects, mammals and one plant species. Comp. Biochem. Physiol. 106C 141-149. 

The triazine herbicides are selective inhibitors of the Hill reaction in plant photosynthesis. In mammals, atrazine disrupts luteinizing hormone and prolactin secretion through direct action on the hypothalamus-pituitary axis. 

Atrazine is slightly toxic to mammals. The NOELs figures obtained during two years of feed trials range from about 1 to about 4 mg/kg daily for rats and dogs respectively (Tomlin, 1994). It can act as a weak, non-genotoxic... 

Herbicides are used to kill plants. Sodium chlorate, NaC103 and sodium arsenite, Na3As03, were commonly used as weed killers in the first half of the twentieth century, but inorganic arsenic compounds, in particular, are toxic to mammals. Organic herbicides are now used. They are much more toxic to certain types of plants than to others, so they can be used as selective weedkillers. Atrazine, which is a member of a class of herbicides called the triazines, is widely used to kill weeds in cornfields. The triazines contain six-membered rings with alternating carbon and nitrogen atoms. The effects of atrazine on human health are not yet clear. 

Data are lacking for atrazine s effects on mammalian wildlife, although there is a growing body of evidence on domestic and small laboratory mammals. Available data demonstrate that mammals are comparatively resistant to atrazine, and that the compoimd is not carcinogenic, mutagenic, or teratogeific. However, there is a reported increase in the... 

Modem herbicides include the triazine herbicides such as atrazine, used to destroy weeds in com fields. Atrazine accumulates in the environment to some degree, but its low toxicity to mammals has allowed its continued use. Other modern herbicides include metolachlor, which is used on soybeans and corn, and paraquat, which has garnered fame for its use in destroying marijuana crops. Neither metolachlor nor paraquat accumulates in the environment, nor does either bioamplify in the food chain. 

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