Atractylodes lancea

YU K w, KiYOHARA H, MATSUMOTO T, YANG H 0, YAMADA H (1998) Intestinal immune system modulating polysaccharides from rhizomes of Atractylodes lancea. Planta Med. 64 714-9. 

Atractylodes lancea Bunge. Cang Zhu (root) Essential oils, atractylon, atractylol.49 As aromatic tonic in chronic gastroenteritis. 

China Atractylodes lancea Bunge. A. chinensis DC A. japonica Koidz. ex Kitam. A. koreana (Nakai) Kitam. A. lancea Bunge. A. ovata DC Atractylone, eudesnol, hinesol.19 Diuretic agent, abdominal and chest tightness, anemia chills, bronchitis cough, diarrhea, CNS suppressing activity. 

Xanthium chinense ., X. strumarium L., X. sibiricum Patr. ex. Widd., X. japonicum Widder, X. mongolicum Kitag. Atractylodes lancea Ampelopsis aconitifolia Amomum globosum Lour. 

Atractylodes lancea, A. chinensis, A. japonica, A. koreana, A. lancea, A. lyrata, A. macrocephala, A. ovata Datura suaveolens... 

Shan-An, H., and Sheng, N. (1997). Utilization and conservation of medicinal plants in China with special reference to Atractylodes lancea. In Medicinal plants for forest conservation and health care. Bodeker, G., Bhat, K.K.S., Burley, J., and Vantomme, P. (eds.) pp. 109— 115. FAO. Rome, Italy. 

Crude extracts from peony root, licorice root, Atractylodes lance a rhizome, and aconite root are traditionally prescribed in medicine clinically to relieve muscle pain and to cure tremors in neuromyopathy. Different kampo preparations include crude extracts from (1) peony and licorice roots (Shakuyaku-kanzo-to), (2) peony, licorice, and aconite roots (Shaku-kan-bushi-to), (3) peony, licorice, ginger roots, cassia cortex, and jujube fruit (Keishi-to), and (4) peony, licorice, aconite, ginger root, Atractylodes lancea rhizome, cassia cortex, and jujube fruit (Keishi-ka-jutubu-to). The main bioactive compounds derived from peony root, licorice root. 

Keishi-ka-jutsubu-to Atractylodes lancea Aconite Ginger eudesmol hypaconitine gingerol Potentiation of block of diabetic neuromuscular synapse Inbibition of ACb release Potentiation of PG-E2, -F2a and -I2-induced vascular contraction ... 

Atractylodes lancea rhizome and aconite root are paeoniflorin, glycyrrhizin, P-eudesmol, and aconitine, respectively. Each compound plays a complementary role, having different mechanisms of action. Their mechanisms in combined (blend) effects of paired or triplet combinations of these compounds have been investigated, and the rationality of the traditional combined medicines has been elucidated. The neuromuscular blocking actions have been compared by using skeletal muscle in vitro and in situ, and in normal and diseased states. 

Compounds 1-4 are glycosides with eudesmane-type sesquiterpene aglycones. Glycosides with the same type of aglycones were also found in another Chinese traditional medicine, Atractylodes lancea (Asteraceae) by a J anese group [8]. 

In 2003, Lu and Du reported the first total synthesis of (—)-hinesol (603) (504). Hinesol is an important component of the Chinese drugs Chang Zhu (Atractylodes lancea var. chinensis) and Baizhu (Alpinia japonica) and shows spasmolytic and... 

Tetrakis(3-methylbutanoyl), 1 -(2S-methylbutanoyl) Atractysucrose Ib C37H62O16 762.887 Constit. of the rhizomes of Atractylodes lancea. 

Atractylodes lancea Thunb. MKN-45 cancer cells. Chenetal. (2013b)... 

Chen, H.-N., Shao, C., Zhao, J.-Z., Guan, X.-W., Ding, J., and Shao, S.-H. (2013b). Essential oil extracted from rhi-zoma of Atractylode lancea induces oncosis in human MKN-45 cancer cells. Eur. J. Inflam, 11(2), 397-403. 

Only a few volatile sesquiterpenes presenting important central activities are currently known. P-Eudesmol (34) was found to be one of the volatile active principles of the Chinese medicinal herb Atractylodes lancea DC. (Asteraceae) with alleged antagonist properties useful in intoxication by anticholinesterase agents of the organophosphorus type (Chiou et al. 1997). Experimental data show that p-eudesmol (34) prevents convulsions and lethality induced by electroshock but not those induced by PTZ or picrotoxin (Chiou et al. 1995). With a very similar chemical structure. 

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