ATP-binding cassette protein

Dolezal P, Likic V, Tachezy J, Lithgow T (2006) Evolution of the molecular machines for protein import into mitochondria. Science 313 314-318 Dong J-S, Lai R, Nielsen K, Fekete CA, Qiu H-F, Hinnebusch AG (2004) The essential ATP-binding cassette protein Rlil functions in translation by promoting preinitiation complex assembly. J Biol Chem 274 42157-42168 Ellis JE, Setchell KD, Kaneshiro ES (1994) Detection of ubiquinone in parasitic and free-living protozoa, including species devoid of mitochondria. Mol Biochem Parasitol 65 213-224... 

PFO puruvateiferredoxin oxidoreductase, HCP hybrid cluster protein, PNO pyruvate NADH oxidoreductase, Nbp35 P-loop NTPase, Nar/Narf hydrogenase-like protein, Rli ATP-binding cassette protein... 

ATP-binding cassette protein ABCG2 Q81X16 Not detected in control cells... 

Michaelis, S., and Berkower, C. (1995). Sequence comparison of yeast ATP-binding cassette proteins. Cold Spring Harb Symp Quant Biol 60 291-307. 

Burke, M.A. and Ardehali, H. (2007) Mitochondrial ATP-binding cassette proteins. Translational Research, 150, 73-80. 

Typical characteristics of the proteins are ATP binding sites (ATP binding cassette proteins). With regard to drug pharmacokinetics, three protein families deserve special interest the MDR proteins, M RP proteins, and breast cancer-related proteins (BCRP). 

Zha X, Gauthier A, Genest J, et al. (2003) Secretory vesicular transport from the Golgi is altered during ATP-binding cassette protein Al (ABCAl)-mediated cholesterol efflux. J Biol Chem 278 10002-10005... 

Legare D, Richard D, Mukopadhyay R, Stier-HOF Y-D, Rosen BP, Haimeur A, Papandopou-Lou B and Quellette (2001) The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase conjugate. 

Reverse cholesterol transport requires a directional movement of cholesterol from the cell to the lipoprotein particle. Cells contain the protein ABCl (ATP-binding cassette protein 1) which uses ATP hydrolysis to move cholesterol from the inner leaflet of the membrane to the outer leaflet. Once the cholesterol has reached the outer membrane leaflet, the HDL particle can accept it, but if the cholesterol is not modified within the HDL particle, the cholesterol can leave the particle by the same route that it entered. To trap the cholesterol within the HDL core, the HDL particle acquires the... 

Apart from the a-TTP-mediated VLDF incorporation and export, secretion of a-tocopherol from cultured cells is also mediated by ABCAl and other not yet characterized processes. ABCAl is an ATP-binding cassette protein that transports cellular cholesterol and phospholipids to lipid-poor high-density lipoproteins (HDF) and apolipoproteins such as apoA-I."" In this study, cells lacking an active ABCAl pathway markedly increased secretion of a-tocopherol to apoA-I after overexpression of ABCAl. 

The metabolism of HDL involves several different enzymes and transfer proteins but is not completely understood [7]. The major apolipoprotein of HDL is apoA-I. The liver and intestine are the sources of apoA-I, which interacts with peripheral cells to remove excess cellular cholesterol via the ATP-binding cassette protein A1 (ABCAl). Unesterified cholesterol associated with nascent HDL is a substrate for the plasma enzyme lecithin cholesterol acyltransferase (LCAT), resulting in the formation of cholesteryl ester and enlargement of the HDL particle. Genetic defects in apoA-I, ABCAl and LCAT can cause low levels of HDL, termed hypoalphalipopro-teinemia. HDL cholesteryl ester is transferred to apoB-containing lipoproteins (such as LDL) by the cholesteryl ester transfer protein (CETP) and can be returned to the liver via the LDL receptor. HDL may also deliver some cholesterol directly to the liver via the scavenger receptor class BI (SR-BI). The removal of excess cholesterol from peripheral cells and delivery to the liver for excretion in the bile is a process that has been termed reverse cholesterol transport . 

Tangier disease ATP-binding cassette protein A1 (ABCAl) All tissues 9q31 205400... 

Shitan N, Bazin I, Dan K, et al. (2003) Involvement of CjMDRl, a plant multidrug-resistance-type ATP-binding cassette protein, in alkaloid transport in Coptis japonica. Proc Natl Acad Sci USA 100 751-756... 

ABCAl is a membrane transport protein belonging to a large family of ATP-binding cassette proteins. These... 

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