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Asymmetric synthesis Jacobsen-Katsuki epoxidation

The Best results are obtained with cA-alkenes however, the epoxidation of tri-and tetra-substituted double bonds is also possible. Because of its versatility, the Jacobsen-Katsuki epoxidation is an important method in asymmetric synthesis. [Pg.256]

The past thirty years have witnessed great advances in the selective synthesis of epoxides, and numerous regio-, chemo-, enantio-, and diastereoselective methods have been developed. Discovered in 1980, the Katsuki-Sharpless catalytic asymmetric epoxidation of allylic alcohols, in which a catalyst for the first time demonstrated both high selectivity and substrate promiscuity, was the first practical entry into the world of chiral 2,3-epoxy alcohols [10, 11]. Asymmetric catalysis of the epoxidation of unfunctionalized olefins through the use of Jacobsen s chiral [(sale-i i) Mi iln] [12] or Shi s chiral ketones [13] as oxidants is also well established. Catalytic asymmetric epoxidations have been comprehensively reviewed [14, 15]. [Pg.447]

Both chemical and enzymatic synthetic methods for the asymmetric oxidation of the carbon-carbon double bond have been developed [46], but the area of carbon-carbon double bond oxidations has been shaped by the breakthrough discovery of asymmetric epoxidation of allylic alcohols with the Katsuki-Sharpless method [47]. Catalytic asymmetric synthesis of epoxides from alkenes by Jacobsen... [Pg.321]

Pozzi G, Banfi S, Manfredi A, Montanari F, Quid S (1996) Tetrahedron 52 11879 Pozzi G, Montanari F, Quid S (1997) J Chem Soc Chem Common 69 a) Jacobsen EN, (1993) Asymmetric Catalytic Epoxidation of Unfunctionalized Olefins. In Ojima I (ed) Catalytic Asymmetric Synthesis. VCH, Weinheim, b) Katsuki T (1996) J Mol Cat 113 87... [Pg.78]


See other pages where Asymmetric synthesis Jacobsen-Katsuki epoxidation is mentioned: [Pg.249]    [Pg.277]    [Pg.279]    [Pg.394]    [Pg.394]    [Pg.403]    [Pg.7]    [Pg.344]    [Pg.91]    [Pg.195]    [Pg.351]    [Pg.51]    [Pg.35]    [Pg.342]    [Pg.272]   
See also in sourсe #XX -- [ Pg.17 , Pg.17 , Pg.18 ]




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Asymmetric epoxidation synthesis

Asymmetric epoxidation, Jacobsen

Epoxidations Jacobsen

Epoxidations, asymmetric

Epoxide synthesis

Epoxides Jacobsen-Katsuki asymmetric synthesis

Epoxides asymmetric epoxidation

Epoxides synthesis

Epoxides, asymmetric synthesis

Jacobsen

Jacobsen epoxidation

Jacobsen-Katsuki

Jacobsen-Katsuki asymmetric

Jacobsen-Katsuki asymmetric epoxidation

Jacobsen-Katsuki epoxidation

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