Astrocytes glial fibrillary acidic protein expression

Toimela TA, Tahti H. 1995. Effects of mercury, methylmercury and aluminum on glial fibrillary acidic protein expression in rat cerebellar astrocyte cultures. Toxicol in Vitro 9 317-325. 

Brahmachaii S, Fung YK and Pahan K (2006) Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide. J Neurosci 26 4930 939. 

Fig. 2. Representative coronal sections of a normothermic and a hypothermic animal 2 mo after 2-h MCAO. Although there is no tissue left in the infarcted area of the normothermic animal, the periinfarct zone still shows reactive astrocytes expressing glial fibrillary acidic protein (GFAP) and manganese-super-oxide dismutase (SOD2) which can be seen as a dark rim around the infarcted area. The hypothermia-treated animal shows a significantly smaller infarct.

BQm BO, Liu Y, Ruan Y, Xu ZC, Schantz L, He JJ (2003) Neuropathologies in transgenic mice expressing human immunodeficiency virus type 1 tat protein under the regulation of the astrocyte-specific glial fibrillary acidic protein promoter and doxycydine. Am J Patliol 162 1693-1707. 

Yoshime T, Maruno M, Kumura E, et al. Stochastic determination of the chromosomal region responsible for expression of human glial fibrillary acidic protein in astrocytic tumors. Neu-rosci Lett. 1998 247 29-32. 

Clatterbuck, R.E., Price, D.L., Koliatsos, V.E., 1996. Ciliary neurotrophic factor stimulates the expression of glial fibrillary acidic protein by brain astrocytes in vivo. J. Comp. Neurol. 369 (4), 543-551. 

Astroglial cells commonly express glial fibrillary acidic protein in their intermediate filaments, at least at some stage during their development. Astrocytes are present throughout the entire central nervous system (CNS), but their density varies considerably in various regions (Pope, 1978). 

Astroglial response to TBI is characterized by hyperplasia and upregulation in glial fibrillary acidic protein (Table 6.2). The reactive astrocytes also express neurotrophic factors, and cytokines, which modulate the generation of recognition molecules allowing the support of post-lesional axonal regrowth. Major... 

In cultured rat aggregated brain cells, 10-20 nmol ochratoxin A/l was shown to increase the expression of genes involved in the brain inflammatory system (messenger ribonucleic acid [mRNA] of peroxisome proliferator-activated receptor, haem oxygenase-1 and inducible nitric oxide synthase) and to reduce the expression of glial fibrillary acidic protein, a constituent of the intermediate filaments in astrocytes (Zurich et al., 2005). 

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