Astrocyte-neuron lactate shuttle

The astrocyte-neuron lactate shuttle hypothesis is controversial 542... 

The astrocyte-neuron lactate shuttle hypothesis is controversial. In recent years the possibility that lactate, formed within the brain and released by astrocytes, is an important neuronal substrate both for energy and incorporation into neurotransmitters has been the subject of many studies and considerable controversy. There is evidence that suggests transient release of lactate in human brain on stimulation [48,8,88], Little is known about the highly active metabolism that takes place in the many elaborate, lamellar distal processes of astrocytes dispersed through the neuropil and interacting with an estimated >100,000 synapses [82, and references therein]. However, it is well established that astrocytes do respond to neuronal activity [89], For example, in the isolated mouse optic nerve preparation, upon stimulation, astrocytic glycogen... 

Pellerin, L., Pellegri, G., Bittar, P. G., Char-nay, Y., Bouras, C., Martin, J. L., Stella, 9 N., Magistretti, P. J. Evidence supporting the existence of an activity-dependent astrocyte-neuron lactate shuttle. Dev. Neu- 10 rosci. 1998, 20 291-299. 

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